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Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers

BACKGROUND: Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-F...

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Detalles Bibliográficos
Autores principales:	Ding, Yuedi, Fan, Jun, Deng, Lili, Huang, Biao, Zhou, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296660/ https://www.ncbi.nlm.nih.gov/pubmed/32549790 http://dx.doi.org/10.1186/s12935-020-01340-6

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