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Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review

BACKGROUND: Pharmacologic therapy is the primary treatment used to manage Parkinson’s disease (PD) symptoms. However, it becomes less effective with time and some symptoms do not respond to medication. Complementary interventions are therefore required for PD. Recent studies have implemented transcr...

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Autores principales: Beretta, Victor Spiandor, Conceição, Núbia Ribeiro, Nóbrega-Sousa, Priscila, Orcioli-Silva, Diego, Dantas, Luana Karla Braz Fonseca, Gobbi, Lilian Teresa Bucken, Vitório, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296764/
https://www.ncbi.nlm.nih.gov/pubmed/32539819
http://dx.doi.org/10.1186/s12984-020-00701-6
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author Beretta, Victor Spiandor
Conceição, Núbia Ribeiro
Nóbrega-Sousa, Priscila
Orcioli-Silva, Diego
Dantas, Luana Karla Braz Fonseca
Gobbi, Lilian Teresa Bucken
Vitório, Rodrigo
author_facet Beretta, Victor Spiandor
Conceição, Núbia Ribeiro
Nóbrega-Sousa, Priscila
Orcioli-Silva, Diego
Dantas, Luana Karla Braz Fonseca
Gobbi, Lilian Teresa Bucken
Vitório, Rodrigo
author_sort Beretta, Victor Spiandor
collection PubMed
description BACKGROUND: Pharmacologic therapy is the primary treatment used to manage Parkinson’s disease (PD) symptoms. However, it becomes less effective with time and some symptoms do not respond to medication. Complementary interventions are therefore required for PD. Recent studies have implemented transcranial direct current stimulation (tDCS) in combination with other modalities of interventions, such as physical and cognitive training. Although the combination of tDCS with physical and cognitive training seems promising, the existing studies present mixed results. Therefore, a systematic review of the literature is necessary. AIMS: This systematic review aims to (i) assess the clinical effects of tDCS when applied in combination with physical or cognitive therapies in people with PD and; (ii) analyze how specific details of the intervention protocols may relate to findings. METHODS: The search strategy detailed the technique of stimulation, population and combined interventions (i.e. cognitive and/or physical training). Only controlled studies were included. RESULTS: Seventeen of an initial yield of 408 studies satisfied the criteria. Studies involved small sample sizes. tDCS protocols and characteristics of combined interventions varied. The reviewed studies suggest that synergistic effects may be obtained for cognition, upper limb function, gait/mobility and posture when tDCS is combined with cognitive and/or motor interventions in PD. CONCLUSION: The reported results encourage further research to better understand the therapeutic utility of tDCS and to inform optimal clinical use in PD. Future studies in this field should focus on determining optimal stimulation parameters and intervention characteristics for maximal benefits in people with PD.
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spelling pubmed-72967642020-06-16 Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review Beretta, Victor Spiandor Conceição, Núbia Ribeiro Nóbrega-Sousa, Priscila Orcioli-Silva, Diego Dantas, Luana Karla Braz Fonseca Gobbi, Lilian Teresa Bucken Vitório, Rodrigo J Neuroeng Rehabil Review BACKGROUND: Pharmacologic therapy is the primary treatment used to manage Parkinson’s disease (PD) symptoms. However, it becomes less effective with time and some symptoms do not respond to medication. Complementary interventions are therefore required for PD. Recent studies have implemented transcranial direct current stimulation (tDCS) in combination with other modalities of interventions, such as physical and cognitive training. Although the combination of tDCS with physical and cognitive training seems promising, the existing studies present mixed results. Therefore, a systematic review of the literature is necessary. AIMS: This systematic review aims to (i) assess the clinical effects of tDCS when applied in combination with physical or cognitive therapies in people with PD and; (ii) analyze how specific details of the intervention protocols may relate to findings. METHODS: The search strategy detailed the technique of stimulation, population and combined interventions (i.e. cognitive and/or physical training). Only controlled studies were included. RESULTS: Seventeen of an initial yield of 408 studies satisfied the criteria. Studies involved small sample sizes. tDCS protocols and characteristics of combined interventions varied. The reviewed studies suggest that synergistic effects may be obtained for cognition, upper limb function, gait/mobility and posture when tDCS is combined with cognitive and/or motor interventions in PD. CONCLUSION: The reported results encourage further research to better understand the therapeutic utility of tDCS and to inform optimal clinical use in PD. Future studies in this field should focus on determining optimal stimulation parameters and intervention characteristics for maximal benefits in people with PD. BioMed Central 2020-06-15 /pmc/articles/PMC7296764/ /pubmed/32539819 http://dx.doi.org/10.1186/s12984-020-00701-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Beretta, Victor Spiandor
Conceição, Núbia Ribeiro
Nóbrega-Sousa, Priscila
Orcioli-Silva, Diego
Dantas, Luana Karla Braz Fonseca
Gobbi, Lilian Teresa Bucken
Vitório, Rodrigo
Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review
title Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review
title_full Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review
title_fullStr Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review
title_full_unstemmed Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review
title_short Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson’s disease: a systematic review
title_sort transcranial direct current stimulation combined with physical or cognitive training in people with parkinson’s disease: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296764/
https://www.ncbi.nlm.nih.gov/pubmed/32539819
http://dx.doi.org/10.1186/s12984-020-00701-6
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