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Impact of maternal overweight and obesity on milk composition and infant growth

Overweight and obesity (OW/OB) impact half of the pregnancies in the United States and can have negative consequences for offspring health. Studies are limited on human milk alterations in the context of maternal obesity. Alterations in milk are hypothesized to impact offspring development during th...

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Autores principales: Ellsworth, Lindsay, Perng, Wei, Harman, Emma, Das, Arun, Pennathur, Subramaniam, Gregg, Brigid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296794/
https://www.ncbi.nlm.nih.gov/pubmed/32074402
http://dx.doi.org/10.1111/mcn.12979
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author Ellsworth, Lindsay
Perng, Wei
Harman, Emma
Das, Arun
Pennathur, Subramaniam
Gregg, Brigid
author_facet Ellsworth, Lindsay
Perng, Wei
Harman, Emma
Das, Arun
Pennathur, Subramaniam
Gregg, Brigid
author_sort Ellsworth, Lindsay
collection PubMed
description Overweight and obesity (OW/OB) impact half of the pregnancies in the United States and can have negative consequences for offspring health. Studies are limited on human milk alterations in the context of maternal obesity. Alterations in milk are hypothesized to impact offspring development during the critical period of lactation. We aimed to evaluate the relationships between mothers with OW/OB (body mass index [BMI] ≥25 kg/m(2)), infant growth, and selected milk nutrients. We recruited mother–infant dyads with pre‐pregnancy OW/OB and normal weight status. The primary study included 52 dyads with infant growth measures through 6 months. Thirty‐two dyads provided milk at 2 weeks, which was analysed for macronutrients, long‐chain fatty acids, and insulin. We used multivariable linear regression to examine the association of maternal weight status with infant growth, maternal weight status with milk components, and milk components with infant growth. Mothers with OW/OB had infants with higher weight‐for‐length (WFL) and BMI Z‐scores at birth. Mothers with OW/OB had higher milk insulin and dihomo‐gamma‐linolenic, adrenic, and palmitic acids and reduced conjugated linoleic and oleic acids. N6 long‐chain polyunsaturated fatty acid (LC‐PUFA)‐driven factor 1 was associated with higher WFL, lower length‐for‐age (LFA), and lower head circumference‐for‐age Z‐scores change from 2 weeks to 2 months in human milk‐fed infants, whereas N6 LC‐PUFA‐driven factor 5 was associated with lower LFA Z‐score change. Human milk composition is associated with maternal pre‐pregnancy weight status and composition may be a contributing factor to early infant growth trajectory.
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spelling pubmed-72967942020-06-17 Impact of maternal overweight and obesity on milk composition and infant growth Ellsworth, Lindsay Perng, Wei Harman, Emma Das, Arun Pennathur, Subramaniam Gregg, Brigid Matern Child Nutr Original Articles Overweight and obesity (OW/OB) impact half of the pregnancies in the United States and can have negative consequences for offspring health. Studies are limited on human milk alterations in the context of maternal obesity. Alterations in milk are hypothesized to impact offspring development during the critical period of lactation. We aimed to evaluate the relationships between mothers with OW/OB (body mass index [BMI] ≥25 kg/m(2)), infant growth, and selected milk nutrients. We recruited mother–infant dyads with pre‐pregnancy OW/OB and normal weight status. The primary study included 52 dyads with infant growth measures through 6 months. Thirty‐two dyads provided milk at 2 weeks, which was analysed for macronutrients, long‐chain fatty acids, and insulin. We used multivariable linear regression to examine the association of maternal weight status with infant growth, maternal weight status with milk components, and milk components with infant growth. Mothers with OW/OB had infants with higher weight‐for‐length (WFL) and BMI Z‐scores at birth. Mothers with OW/OB had higher milk insulin and dihomo‐gamma‐linolenic, adrenic, and palmitic acids and reduced conjugated linoleic and oleic acids. N6 long‐chain polyunsaturated fatty acid (LC‐PUFA)‐driven factor 1 was associated with higher WFL, lower length‐for‐age (LFA), and lower head circumference‐for‐age Z‐scores change from 2 weeks to 2 months in human milk‐fed infants, whereas N6 LC‐PUFA‐driven factor 5 was associated with lower LFA Z‐score change. Human milk composition is associated with maternal pre‐pregnancy weight status and composition may be a contributing factor to early infant growth trajectory. John Wiley and Sons Inc. 2020-02-19 /pmc/articles/PMC7296794/ /pubmed/32074402 http://dx.doi.org/10.1111/mcn.12979 Text en © 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Ellsworth, Lindsay
Perng, Wei
Harman, Emma
Das, Arun
Pennathur, Subramaniam
Gregg, Brigid
Impact of maternal overweight and obesity on milk composition and infant growth
title Impact of maternal overweight and obesity on milk composition and infant growth
title_full Impact of maternal overweight and obesity on milk composition and infant growth
title_fullStr Impact of maternal overweight and obesity on milk composition and infant growth
title_full_unstemmed Impact of maternal overweight and obesity on milk composition and infant growth
title_short Impact of maternal overweight and obesity on milk composition and infant growth
title_sort impact of maternal overweight and obesity on milk composition and infant growth
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296794/
https://www.ncbi.nlm.nih.gov/pubmed/32074402
http://dx.doi.org/10.1111/mcn.12979
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