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Pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in Ethiopia

The overarching Ethiopia project examined the effects of early market introduction of iodized salt on the growth and mental development of young children. Sixty districts were randomly assigned to intervention (early market access to iodized salt) or control (later access through market forces), and...

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Autores principales: Mohammed, Husein, Marquis, Grace S., Aboud, Frances, Bougma, Karim, Samuel, Aregash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296810/
https://www.ncbi.nlm.nih.gov/pubmed/31912649
http://dx.doi.org/10.1111/mcn.12943
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author Mohammed, Husein
Marquis, Grace S.
Aboud, Frances
Bougma, Karim
Samuel, Aregash
author_facet Mohammed, Husein
Marquis, Grace S.
Aboud, Frances
Bougma, Karim
Samuel, Aregash
author_sort Mohammed, Husein
collection PubMed
description The overarching Ethiopia project examined the effects of early market introduction of iodized salt on the growth and mental development of young children. Sixty districts were randomly assigned to intervention (early market access to iodized salt) or control (later access through market forces), and one community per district was randomly chosen as the sampling unit. For this project, 22 of the districts were included. The participants were 1,220 pregnant women who conceived after the intervention began. When their children were 2 to 13 months old, field staff collected information on household sociodemographic status and iodized salt intake, child stimulation, maternal depression symptoms, children's diet, anthropometry, urinary iodine concentration (UIC), hemoglobin, and mental development scores (Bayley III scales). Fewer mothers prepartum (28% vs. 41%, p < .05) and their children (13% vs. 20%, p < .05) were iodine deficient (UIC <50 μg/L) in the intervention compared with the control group. The intervention children had higher cognitive scores (33.3 ± 0.3 vs. 32.6 ± 0.3; Δ = 0.6; 95% CI [0.0, 1.3]; d = 0.17; p = .01; 4 IQ points) than their controls. The other Bayley subscale scores did not differ from control children. The intervention group had a higher child stimulation (22.7 ± 0.2 vs. 22.1 ± 0.2; Δ = 0.5; 95% CI [0.02, 0.89]; d = 0.17; p = .01) but not growth indicators (weight‐for‐age z score, length‐for‐age z score, and weight‐for‐length z score: −1.1 ± 0.1 vs. −1.1 ± 0.1, −1.7 ± 0.1 vs. −1.7 ± 0.1; −0.2 ± 0.1 vs. −0.1 ± 0.1, respectively, all p > .05) compared with their controls. Iodized salt intake improved iodine status of both pregnant women and their children and also child cognitive development.
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spelling pubmed-72968102020-06-17 Pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in Ethiopia Mohammed, Husein Marquis, Grace S. Aboud, Frances Bougma, Karim Samuel, Aregash Matern Child Nutr Original Articles The overarching Ethiopia project examined the effects of early market introduction of iodized salt on the growth and mental development of young children. Sixty districts were randomly assigned to intervention (early market access to iodized salt) or control (later access through market forces), and one community per district was randomly chosen as the sampling unit. For this project, 22 of the districts were included. The participants were 1,220 pregnant women who conceived after the intervention began. When their children were 2 to 13 months old, field staff collected information on household sociodemographic status and iodized salt intake, child stimulation, maternal depression symptoms, children's diet, anthropometry, urinary iodine concentration (UIC), hemoglobin, and mental development scores (Bayley III scales). Fewer mothers prepartum (28% vs. 41%, p < .05) and their children (13% vs. 20%, p < .05) were iodine deficient (UIC <50 μg/L) in the intervention compared with the control group. The intervention children had higher cognitive scores (33.3 ± 0.3 vs. 32.6 ± 0.3; Δ = 0.6; 95% CI [0.0, 1.3]; d = 0.17; p = .01; 4 IQ points) than their controls. The other Bayley subscale scores did not differ from control children. The intervention group had a higher child stimulation (22.7 ± 0.2 vs. 22.1 ± 0.2; Δ = 0.5; 95% CI [0.02, 0.89]; d = 0.17; p = .01) but not growth indicators (weight‐for‐age z score, length‐for‐age z score, and weight‐for‐length z score: −1.1 ± 0.1 vs. −1.1 ± 0.1, −1.7 ± 0.1 vs. −1.7 ± 0.1; −0.2 ± 0.1 vs. −0.1 ± 0.1, respectively, all p > .05) compared with their controls. Iodized salt intake improved iodine status of both pregnant women and their children and also child cognitive development. John Wiley and Sons Inc. 2020-01-07 /pmc/articles/PMC7296810/ /pubmed/31912649 http://dx.doi.org/10.1111/mcn.12943 Text en © 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Mohammed, Husein
Marquis, Grace S.
Aboud, Frances
Bougma, Karim
Samuel, Aregash
Pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in Ethiopia
title Pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in Ethiopia
title_full Pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in Ethiopia
title_fullStr Pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in Ethiopia
title_full_unstemmed Pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in Ethiopia
title_short Pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in Ethiopia
title_sort pre‐pregnancy iodized salt improved children's cognitive development in randomized trial in ethiopia
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296810/
https://www.ncbi.nlm.nih.gov/pubmed/31912649
http://dx.doi.org/10.1111/mcn.12943
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