Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms

Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in patients with limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal antibodies (mAbs) against LGI1. We explore their sequences and binding characteristics, plus their pathogenic potential usin...

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Detalles Bibliográficos
Autores principales: Ramberger, Melanie, Berretta, Antonio, Tan, Jeanne M M, Sun, Bo, Michael, Sophia, Yeo, Tianrong, Theorell, Jakob, Bashford-Rogers, Rachael, Paneva, Sofija, O’Dowd, Victoria, Dedi, Neesha, Topia, Sarfaraj, Griffin, Robert, Ramirez-Franco, Jorge, El Far, Oussama, Baulac, Stéphanie, Leite, Maria I, Sen, Arjune, Jeans, Alexander, McMillan, David, Marshall, Diane, Anthony, Daniel, Lightwood, Daniel, Waters, Patrick, Irani, Sarosh R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296845/
https://www.ncbi.nlm.nih.gov/pubmed/32437528
http://dx.doi.org/10.1093/brain/awaa104

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