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The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications
Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in adults. As there is no cure, thousands of individuals who are alive at present will succumb to the disease. In recent years, numerous causative genes and risk factors for amyotrophic lateral sclerosis have bee...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296858/ https://www.ncbi.nlm.nih.gov/pubmed/32206784 http://dx.doi.org/10.1093/brain/awaa022 |
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author | Guo, Wenting Vandoorne, Tijs Steyaert, Jolien Staats, Kim A Van Den Bosch, Ludo |
author_facet | Guo, Wenting Vandoorne, Tijs Steyaert, Jolien Staats, Kim A Van Den Bosch, Ludo |
author_sort | Guo, Wenting |
collection | PubMed |
description | Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in adults. As there is no cure, thousands of individuals who are alive at present will succumb to the disease. In recent years, numerous causative genes and risk factors for amyotrophic lateral sclerosis have been identified. Several of the recently identified genes encode kinases. In addition, the hypothesis that (de)phosphorylation processes drive the disease process resulting in selective motor neuron degeneration in different disease variants has been postulated. We re-evaluate the evidence for this hypothesis based on recent findings and discuss the multiple roles of kinases in amyotrophic lateral sclerosis pathogenesis. We propose that kinases could represent promising therapeutic targets. Mainly due to the comprehensive regulation of kinases, however, a better understanding of the disturbances in the kinome network in amyotrophic lateral sclerosis is needed to properly target specific kinases in the clinic. |
format | Online Article Text |
id | pubmed-7296858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-72968582020-06-22 The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications Guo, Wenting Vandoorne, Tijs Steyaert, Jolien Staats, Kim A Van Den Bosch, Ludo Brain Review Articles Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in adults. As there is no cure, thousands of individuals who are alive at present will succumb to the disease. In recent years, numerous causative genes and risk factors for amyotrophic lateral sclerosis have been identified. Several of the recently identified genes encode kinases. In addition, the hypothesis that (de)phosphorylation processes drive the disease process resulting in selective motor neuron degeneration in different disease variants has been postulated. We re-evaluate the evidence for this hypothesis based on recent findings and discuss the multiple roles of kinases in amyotrophic lateral sclerosis pathogenesis. We propose that kinases could represent promising therapeutic targets. Mainly due to the comprehensive regulation of kinases, however, a better understanding of the disturbances in the kinome network in amyotrophic lateral sclerosis is needed to properly target specific kinases in the clinic. Oxford University Press 2020-06 2020-03-24 /pmc/articles/PMC7296858/ /pubmed/32206784 http://dx.doi.org/10.1093/brain/awaa022 Text en © The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Review Articles Guo, Wenting Vandoorne, Tijs Steyaert, Jolien Staats, Kim A Van Den Bosch, Ludo The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications |
title | The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications |
title_full | The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications |
title_fullStr | The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications |
title_full_unstemmed | The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications |
title_short | The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications |
title_sort | multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296858/ https://www.ncbi.nlm.nih.gov/pubmed/32206784 http://dx.doi.org/10.1093/brain/awaa022 |
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