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Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review
Inflammation is identified as a keystone of atherosclerosis. This review of the literature explores the unique anti-inflammatory effects of colchicine and summarizes the mechanisms of inflammation in acute coronary syndrome. It outlines other therapeutic strategies employed until now to target coron...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296886/ https://www.ncbi.nlm.nih.gov/pubmed/32550081 http://dx.doi.org/10.7759/cureus.8166 |
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author | Malik, Jahanzeb Javed, Nismat Ishaq, Uzma Khan, Umar Laique, Talha |
author_facet | Malik, Jahanzeb Javed, Nismat Ishaq, Uzma Khan, Umar Laique, Talha |
author_sort | Malik, Jahanzeb |
collection | PubMed |
description | Inflammation is identified as a keystone of atherosclerosis. This review of the literature explores the unique anti-inflammatory effects of colchicine and summarizes the mechanisms of inflammation in acute coronary syndrome. It outlines other therapeutic strategies employed until now to target coronary inflammation and analyzes the role of colchicine in improving the outcomes of acute coronary syndrome. Despite the existence of guideline-directed medical therapy, there still remains a higher risk for recurrence due to continuous inflammation at remaining vascular sites. Several anti-inflammatory strategies have been employed, but they have not been shown to be beneficial. However, colchicine is becoming increasingly popular in tackling this problem. For this review, databases were searched for trials on the role of colchicine as an anti-inflammatory therapy in acute coronary syndrome. |
format | Online Article Text |
id | pubmed-7296886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-72968862020-06-16 Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review Malik, Jahanzeb Javed, Nismat Ishaq, Uzma Khan, Umar Laique, Talha Cureus Cardiology Inflammation is identified as a keystone of atherosclerosis. This review of the literature explores the unique anti-inflammatory effects of colchicine and summarizes the mechanisms of inflammation in acute coronary syndrome. It outlines other therapeutic strategies employed until now to target coronary inflammation and analyzes the role of colchicine in improving the outcomes of acute coronary syndrome. Despite the existence of guideline-directed medical therapy, there still remains a higher risk for recurrence due to continuous inflammation at remaining vascular sites. Several anti-inflammatory strategies have been employed, but they have not been shown to be beneficial. However, colchicine is becoming increasingly popular in tackling this problem. For this review, databases were searched for trials on the role of colchicine as an anti-inflammatory therapy in acute coronary syndrome. Cureus 2020-05-17 /pmc/articles/PMC7296886/ /pubmed/32550081 http://dx.doi.org/10.7759/cureus.8166 Text en Copyright © 2020, Malik et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Cardiology Malik, Jahanzeb Javed, Nismat Ishaq, Uzma Khan, Umar Laique, Talha Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review |
title | Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review |
title_full | Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review |
title_fullStr | Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review |
title_full_unstemmed | Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review |
title_short | Is There a Role for Colchicine in Acute Coronary Syndromes? A Literature Review |
title_sort | is there a role for colchicine in acute coronary syndromes? a literature review |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296886/ https://www.ncbi.nlm.nih.gov/pubmed/32550081 http://dx.doi.org/10.7759/cureus.8166 |
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