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Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma

BACKGROUND: Colon adenocarcinoma (COAD) is the most common form of colon cancer. The glutathione S-transferase Mu (GSTM) gene belongs to the GST gene family, which functions in cell metabolism and detoxification. The relationship between GSTM and COAD and the underlying mechanism remain unknown. MET...

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Autores principales: Guo, Erna, Wei, Haotang, Liao, Xiwen, Wu, Liuyu, Zeng, Xiaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296959/
https://www.ncbi.nlm.nih.gov/pubmed/32539715
http://dx.doi.org/10.1186/s12881-020-01066-2
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author Guo, Erna
Wei, Haotang
Liao, Xiwen
Wu, Liuyu
Zeng, Xiaoyun
author_facet Guo, Erna
Wei, Haotang
Liao, Xiwen
Wu, Liuyu
Zeng, Xiaoyun
author_sort Guo, Erna
collection PubMed
description BACKGROUND: Colon adenocarcinoma (COAD) is the most common form of colon cancer. The glutathione S-transferase Mu (GSTM) gene belongs to the GST gene family, which functions in cell metabolism and detoxification. The relationship between GSTM and COAD and the underlying mechanism remain unknown. METHODS: Data extracted from The Cancer Genome Atlas included mRNA expression and clinical information such as gender, age, and tumor stage. Prognostic values of GSTM genes were identified by survival analysis. Function and mechanism of prognostic GSTM genes were identified by gene set enrichment analysis. A nomogram was used to predict the contribution of risk factors to the outcome of COAD patients. RESULTS: Low expression of GSTM1 and GSTM2 was related to favorable OS (adjusted P = 0.006, adjusted HR = 0.559, 95% CI = 0.367–0.849 and adjusted P = 0.002, adjusted HR = 0.519, 95% CI = 0.342–0.790, respectively) after adjusting for tumor stage. Enrichment analysis also showed that genes involved were related to cell cycle, metabolism, and detoxification processes, as well as the Wnt signaling and NF-κB pathways. CONCLUSIONS: In conclusion, low expression of GSTM1 and GSTM2 were significantly associated with favorable prognosis in COAD. These two genes may serve as potential biomarkers of COAD prognosis.
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spelling pubmed-72969592020-06-16 Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma Guo, Erna Wei, Haotang Liao, Xiwen Wu, Liuyu Zeng, Xiaoyun BMC Med Genet Research Article BACKGROUND: Colon adenocarcinoma (COAD) is the most common form of colon cancer. The glutathione S-transferase Mu (GSTM) gene belongs to the GST gene family, which functions in cell metabolism and detoxification. The relationship between GSTM and COAD and the underlying mechanism remain unknown. METHODS: Data extracted from The Cancer Genome Atlas included mRNA expression and clinical information such as gender, age, and tumor stage. Prognostic values of GSTM genes were identified by survival analysis. Function and mechanism of prognostic GSTM genes were identified by gene set enrichment analysis. A nomogram was used to predict the contribution of risk factors to the outcome of COAD patients. RESULTS: Low expression of GSTM1 and GSTM2 was related to favorable OS (adjusted P = 0.006, adjusted HR = 0.559, 95% CI = 0.367–0.849 and adjusted P = 0.002, adjusted HR = 0.519, 95% CI = 0.342–0.790, respectively) after adjusting for tumor stage. Enrichment analysis also showed that genes involved were related to cell cycle, metabolism, and detoxification processes, as well as the Wnt signaling and NF-κB pathways. CONCLUSIONS: In conclusion, low expression of GSTM1 and GSTM2 were significantly associated with favorable prognosis in COAD. These two genes may serve as potential biomarkers of COAD prognosis. BioMed Central 2020-06-15 /pmc/articles/PMC7296959/ /pubmed/32539715 http://dx.doi.org/10.1186/s12881-020-01066-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Guo, Erna
Wei, Haotang
Liao, Xiwen
Wu, Liuyu
Zeng, Xiaoyun
Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma
title Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma
title_full Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma
title_fullStr Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma
title_full_unstemmed Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma
title_short Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma
title_sort clinical significance and biological mechanisms of glutathione s-transferase mu gene family in colon adenocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296959/
https://www.ncbi.nlm.nih.gov/pubmed/32539715
http://dx.doi.org/10.1186/s12881-020-01066-2
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