Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level

Rapid resuscitation of an opioid overdose with naloxone, an opioid antagonist, is critical. We developed an opioid receptor quantitative systems pharmacology (QSP) model for evaluation of naloxone dosing. In this model we examined three opioid exposure levels that have been reported in the literatur...

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Detalles Bibliográficos
Autores principales: Moss, Ronald B., Pryor, Meghan McCabe, Baillie, Rebecca, Kudrycki, Katherine, Friedrich, Christina, Reed, Mike, Carlo, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297366/
https://www.ncbi.nlm.nih.gov/pubmed/32544184
http://dx.doi.org/10.1371/journal.pone.0234683

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