Pre-existing minor variants with NS5A L31M/V-Y93H double substitution are closely linked to virologic failure with asunaprevir plus daclatasvir treatment for genotype 1b hepatitis C virus infection

BACKGROUND: L31 and Y93 in the NS5A region of the hepatitis C virus (HCV) are the most important substitution positions associated with resistance to direct-acting antiviral (DAA) treatment. METHODS: We analyzed the frequency of NS5A L31M/V and Y93/H in NS5A inhibitor-naive HCV genotype 1 patients w...

Descripción completa

Detalles Bibliográficos
Autores principales: Morishita, Naoki, Sakamori, Ryotaro, Yamada, Tomomi, Kai, Yugo, Tahata, Yuki, Urabe, Ayako, Yamada, Ryoko, Kodama, Takahiro, Hikita, Hayato, Doi, Yoshinori, Tamura, Shinji, Hagiwara, Hideki, Imai, Yasuharu, Iio, Sadaharu, Tatsumi, Tomohide, Takehara, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297368/
https://www.ncbi.nlm.nih.gov/pubmed/32544182
http://dx.doi.org/10.1371/journal.pone.0234811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297368/
https://www.ncbi.nlm.nih.gov/pubmed/32544182
http://dx.doi.org/10.1371/journal.pone.0234811

Ejemplares similares