GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation

Urogenital tract abnormalities are among the most common congenital defects in humans. Male urogenital development requires Hedgehog-GLI signaling and testicular hormones, but how these pathways interact is unclear. We found that Gli3(XtJ) mutant mice exhibit cryptorchidism and hypospadias due to lo...

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Detalles Bibliográficos
Autores principales: Kothandapani, Anbarasi, Lewis, Samantha R., Noel, Jessica L., Zacharski, Abbey, Krellwitz, Kyle, Baines, Anna, Winske, Stephanie, Vezina, Chad M., Kaftanovskaya, Elena M., Agoulnik, Alexander I., Merton, Emily M., Cohn, Martin J., Jorgensen, Joan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297385/
https://www.ncbi.nlm.nih.gov/pubmed/32497091
http://dx.doi.org/10.1371/journal.pgen.1008810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297385/
https://www.ncbi.nlm.nih.gov/pubmed/32497091
http://dx.doi.org/10.1371/journal.pgen.1008810

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