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Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains

Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems are activated during such decisions. In previous work in humans, we found that evoked responses of arousal systems during decisions are reported by rapid dilations of the pupil and track a suppression...

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Autores principales: de Gee, Jan Willem, Tsetsos, Konstantinos, Schwabe, Lars, Urai, Anne E, McCormick, David, McGinley, Matthew J, Donner, Tobias H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297536/
https://www.ncbi.nlm.nih.gov/pubmed/32543372
http://dx.doi.org/10.7554/eLife.54014
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author de Gee, Jan Willem
Tsetsos, Konstantinos
Schwabe, Lars
Urai, Anne E
McCormick, David
McGinley, Matthew J
Donner, Tobias H
author_facet de Gee, Jan Willem
Tsetsos, Konstantinos
Schwabe, Lars
Urai, Anne E
McCormick, David
McGinley, Matthew J
Donner, Tobias H
author_sort de Gee, Jan Willem
collection PubMed
description Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems are activated during such decisions. In previous work in humans, we found that evoked responses of arousal systems during decisions are reported by rapid dilations of the pupil and track a suppression of biases in the accumulation of decision-relevant evidence (de Gee et al., 2017). Here, we show that this arousal-related suppression in decision bias acts on both conservative and liberal biases, and generalizes from humans to mice, and from perceptual to memory-based decisions. In challenging sound-detection tasks, the impact of spontaneous or experimentally induced choice biases was reduced under high phasic arousal. Similar bias suppression occurred when evidence was drawn from memory. All of these behavioral effects were explained by reduced evidence accumulation biases. Our results point to a general principle of interplay between phasic arousal and decision-making.
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spelling pubmed-72975362020-06-18 Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains de Gee, Jan Willem Tsetsos, Konstantinos Schwabe, Lars Urai, Anne E McCormick, David McGinley, Matthew J Donner, Tobias H eLife Neuroscience Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems are activated during such decisions. In previous work in humans, we found that evoked responses of arousal systems during decisions are reported by rapid dilations of the pupil and track a suppression of biases in the accumulation of decision-relevant evidence (de Gee et al., 2017). Here, we show that this arousal-related suppression in decision bias acts on both conservative and liberal biases, and generalizes from humans to mice, and from perceptual to memory-based decisions. In challenging sound-detection tasks, the impact of spontaneous or experimentally induced choice biases was reduced under high phasic arousal. Similar bias suppression occurred when evidence was drawn from memory. All of these behavioral effects were explained by reduced evidence accumulation biases. Our results point to a general principle of interplay between phasic arousal and decision-making. eLife Sciences Publications, Ltd 2020-06-16 /pmc/articles/PMC7297536/ /pubmed/32543372 http://dx.doi.org/10.7554/eLife.54014 Text en © 2020, de Gee et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
de Gee, Jan Willem
Tsetsos, Konstantinos
Schwabe, Lars
Urai, Anne E
McCormick, David
McGinley, Matthew J
Donner, Tobias H
Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
title Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
title_full Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
title_fullStr Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
title_full_unstemmed Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
title_short Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
title_sort pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297536/
https://www.ncbi.nlm.nih.gov/pubmed/32543372
http://dx.doi.org/10.7554/eLife.54014
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