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Spectrum of neuropsychiatric manifestations in COVID-19

Corona Virus Disease 2019 (COVID-19) emerged in December 2019 from Wuhan, China. It typically presents with mild upper respiratory tract infection symptoms and may have life threatening complications, including acute respiratory distress syndrome, acute stroke, myocardial infarction, kidney failure,...

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Autores principales: Nalleballe, Krishna, Reddy Onteddu, Sanjeeva, Sharma, Rohan, Dandu, Vasuki, Brown, Aliza, Jasti, Madhu, Yadala, Sisira, Veerapaneni, Karthika, Siddamreddy, Suman, Avula, Akshay, Kapoor, Nidhi, Mudassar, Kamran, Kovvuru, Sukanthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297688/
https://www.ncbi.nlm.nih.gov/pubmed/32561222
http://dx.doi.org/10.1016/j.bbi.2020.06.020
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author Nalleballe, Krishna
Reddy Onteddu, Sanjeeva
Sharma, Rohan
Dandu, Vasuki
Brown, Aliza
Jasti, Madhu
Yadala, Sisira
Veerapaneni, Karthika
Siddamreddy, Suman
Avula, Akshay
Kapoor, Nidhi
Mudassar, Kamran
Kovvuru, Sukanthi
author_facet Nalleballe, Krishna
Reddy Onteddu, Sanjeeva
Sharma, Rohan
Dandu, Vasuki
Brown, Aliza
Jasti, Madhu
Yadala, Sisira
Veerapaneni, Karthika
Siddamreddy, Suman
Avula, Akshay
Kapoor, Nidhi
Mudassar, Kamran
Kovvuru, Sukanthi
author_sort Nalleballe, Krishna
collection PubMed
description Corona Virus Disease 2019 (COVID-19) emerged in December 2019 from Wuhan, China. It typically presents with mild upper respiratory tract infection symptoms and may have life threatening complications, including acute respiratory distress syndrome, acute stroke, myocardial infarction, kidney failure, shock, and even death. Coronavirus infections are known to have neuroinvasive potential with consequent neuropsychiatric manifestations. We analyzed COVID-19 adult patients in the TriNetX database, which is a global health collaborative clinical research platform collecting real-time electronic medical records data from a network of health care organizations (HCOs) from January 20, 2020 to June 10th, 2020. 40,469 patients were diagnosed with COVID-19 among whom 9086 (22.5%) patients had neuropsychiatric manifestations. The most common neurologic manifestations included headache (3.7%) and sleep disorders (3.4%), Encephalopathy (2.3%), Stroke and transient ischemic attack (TIA) (1.0%) and 0.6% had seizures. Most common psychiatric manifestations included anxiety and other related disorders (4.6%), mood disorders (3.8%), while 0.2% patients had suicidal ideation. Early recognition and prompt management of neuropsychiatric manifestations in these patients have a potential to decrease overall morbidity and mortality.
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spelling pubmed-72976882020-06-17 Spectrum of neuropsychiatric manifestations in COVID-19 Nalleballe, Krishna Reddy Onteddu, Sanjeeva Sharma, Rohan Dandu, Vasuki Brown, Aliza Jasti, Madhu Yadala, Sisira Veerapaneni, Karthika Siddamreddy, Suman Avula, Akshay Kapoor, Nidhi Mudassar, Kamran Kovvuru, Sukanthi Brain Behav Immun Short Communication Corona Virus Disease 2019 (COVID-19) emerged in December 2019 from Wuhan, China. It typically presents with mild upper respiratory tract infection symptoms and may have life threatening complications, including acute respiratory distress syndrome, acute stroke, myocardial infarction, kidney failure, shock, and even death. Coronavirus infections are known to have neuroinvasive potential with consequent neuropsychiatric manifestations. We analyzed COVID-19 adult patients in the TriNetX database, which is a global health collaborative clinical research platform collecting real-time electronic medical records data from a network of health care organizations (HCOs) from January 20, 2020 to June 10th, 2020. 40,469 patients were diagnosed with COVID-19 among whom 9086 (22.5%) patients had neuropsychiatric manifestations. The most common neurologic manifestations included headache (3.7%) and sleep disorders (3.4%), Encephalopathy (2.3%), Stroke and transient ischemic attack (TIA) (1.0%) and 0.6% had seizures. Most common psychiatric manifestations included anxiety and other related disorders (4.6%), mood disorders (3.8%), while 0.2% patients had suicidal ideation. Early recognition and prompt management of neuropsychiatric manifestations in these patients have a potential to decrease overall morbidity and mortality. Elsevier Inc. 2020-08 2020-06-17 /pmc/articles/PMC7297688/ /pubmed/32561222 http://dx.doi.org/10.1016/j.bbi.2020.06.020 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Nalleballe, Krishna
Reddy Onteddu, Sanjeeva
Sharma, Rohan
Dandu, Vasuki
Brown, Aliza
Jasti, Madhu
Yadala, Sisira
Veerapaneni, Karthika
Siddamreddy, Suman
Avula, Akshay
Kapoor, Nidhi
Mudassar, Kamran
Kovvuru, Sukanthi
Spectrum of neuropsychiatric manifestations in COVID-19
title Spectrum of neuropsychiatric manifestations in COVID-19
title_full Spectrum of neuropsychiatric manifestations in COVID-19
title_fullStr Spectrum of neuropsychiatric manifestations in COVID-19
title_full_unstemmed Spectrum of neuropsychiatric manifestations in COVID-19
title_short Spectrum of neuropsychiatric manifestations in COVID-19
title_sort spectrum of neuropsychiatric manifestations in covid-19
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297688/
https://www.ncbi.nlm.nih.gov/pubmed/32561222
http://dx.doi.org/10.1016/j.bbi.2020.06.020
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