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Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders
Neurodevelopmental psychiatric disorders including schizophrenia (Sz) and attention deficit hyperactivity disorder (ADHD) are chronic mental illnesses, which place costly and painful burdens on patients, their families and society. In recent years, the epidermal growth factor (EGF) family member Neu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297728/ https://www.ncbi.nlm.nih.gov/pubmed/32546684 http://dx.doi.org/10.1038/s41398-020-00868-5 |
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author | Shi, Liang Bergson, Clare M. |
author_facet | Shi, Liang Bergson, Clare M. |
author_sort | Shi, Liang |
collection | PubMed |
description | Neurodevelopmental psychiatric disorders including schizophrenia (Sz) and attention deficit hyperactivity disorder (ADHD) are chronic mental illnesses, which place costly and painful burdens on patients, their families and society. In recent years, the epidermal growth factor (EGF) family member Neuregulin 1 (NRG1) and one of its receptors, ErbB4, have received considerable attention due to their regulation of inhibitory local neural circuit mechanisms important for information processing, attention, and cognitive flexibility. Here we examine an emerging body of work indicating that either decreasing NRG1–ErbB4 signaling in fast-spiking parvalbumin positive (PV+) interneurons or increasing it in vasoactive intestinal peptide positive (VIP+) interneurons could reactivate cortical plasticity, potentially making it a future target for gene therapy in adults with neurodevelopmental disorders. We propose preclinical studies to explore this model in prefrontal cortex (PFC), but also review the many challenges in pursuing cell type and brain-region-specific therapeutic approaches for the NRG1 system. |
format | Online Article Text |
id | pubmed-7297728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72977282020-06-22 Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders Shi, Liang Bergson, Clare M. Transl Psychiatry Review Article Neurodevelopmental psychiatric disorders including schizophrenia (Sz) and attention deficit hyperactivity disorder (ADHD) are chronic mental illnesses, which place costly and painful burdens on patients, their families and society. In recent years, the epidermal growth factor (EGF) family member Neuregulin 1 (NRG1) and one of its receptors, ErbB4, have received considerable attention due to their regulation of inhibitory local neural circuit mechanisms important for information processing, attention, and cognitive flexibility. Here we examine an emerging body of work indicating that either decreasing NRG1–ErbB4 signaling in fast-spiking parvalbumin positive (PV+) interneurons or increasing it in vasoactive intestinal peptide positive (VIP+) interneurons could reactivate cortical plasticity, potentially making it a future target for gene therapy in adults with neurodevelopmental disorders. We propose preclinical studies to explore this model in prefrontal cortex (PFC), but also review the many challenges in pursuing cell type and brain-region-specific therapeutic approaches for the NRG1 system. Nature Publishing Group UK 2020-06-16 /pmc/articles/PMC7297728/ /pubmed/32546684 http://dx.doi.org/10.1038/s41398-020-00868-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Shi, Liang Bergson, Clare M. Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders |
title | Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders |
title_full | Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders |
title_fullStr | Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders |
title_full_unstemmed | Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders |
title_short | Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders |
title_sort | neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297728/ https://www.ncbi.nlm.nih.gov/pubmed/32546684 http://dx.doi.org/10.1038/s41398-020-00868-5 |
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