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Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297733/ https://www.ncbi.nlm.nih.gov/pubmed/32546718 http://dx.doi.org/10.1038/s41467-020-16765-w |
| _version_ | 1783547067974549504 |
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| author | Strakova, Andrea Nicholls, Thomas J. Baez-Ortega, Adrian Ní Leathlobhair, Máire Sampson, Alexander T. Hughes, Katherine Bolton, Isobelle A. G. Gori, Kevin Wang, Jinhong Airikkala-Otter, Ilona Allen, Janice L. Allum, Karen M. Arnold, Clara L. Bansse-Issa, Leontine Bhutia, Thinlay N. Bisson, Jocelyn L. Blank, Kelli Briceño, Cristóbal Castillo Domracheva, Artemio Corrigan, Anne M. Cran, Hugh R. Crawford, Jane T. Cutter, Stephen M. Davis, Eric de Castro, Karina F. De Nardi, Andrigo B. de Vos, Anna P. Delgadillo Keenan, Laura Donelan, Edward M. Espinoza Huerta, Adela R. Faramade, Ibikunle A. Fazil, Mohammed Fotopoulou, Eleni Fruean, Skye N. Gallardo-Arrieta, Fanny Glebova, Olga Gouletsou, Pagona G. Häfelin Manrique, Rodrigo F. Henriques, Joaquim J. G. P. Horta, Rodrigo S. Ignatenko, Natalia Kane, Yaghouba King, Cathy Koenig, Debbie Krupa, Ada Kruzeniski, Steven J. Lanza-Perea, Marta Lazyan, Mihran Lopez Quintana, Adriana M. Losfelt, Thibault Marino, Gabriele Martínez Castañeda, Simón Martínez-López, Mayra F. Masuruli, Bedan M. Meyer, Michael Migneco, Edward J. Nakanwagi, Berna Neal, Karter B. Neunzig, Winifred Nixon, Sally J. Ortega-Pacheco, Antonio Pedraza-Ordoñez, Francisco Peleteiro, Maria C. Polak, Katherine Pye, Ruth J. Ramirez-Ante, Juan C. Reece, John F. Rojas Gutierrez, Jose Sadia, Haleema Schmeling, Sheila K. Shamanova, Olga Sherlock, Alan G. Steenland-Smit, Audrey E. Svitich, Alla Tapia Martínez, Lester J. Thoya Ngoka, Ismail Torres, Cristian G. Tudor, Elizabeth M. van der Wel, Mirjam G. Vițălaru, Bogdan A. Vural, Sevil A. Walkinton, Oliver Wehrle-Martinez, Alvaro S. Widdowson, Sophie A. E. Zvarich, Irina Chinnery, Patrick F. Falkenberg, Maria Gustafsson, Claes M. Murchison, Elizabeth P. |
| author_facet | Strakova, Andrea Nicholls, Thomas J. Baez-Ortega, Adrian Ní Leathlobhair, Máire Sampson, Alexander T. Hughes, Katherine Bolton, Isobelle A. G. Gori, Kevin Wang, Jinhong Airikkala-Otter, Ilona Allen, Janice L. Allum, Karen M. Arnold, Clara L. Bansse-Issa, Leontine Bhutia, Thinlay N. Bisson, Jocelyn L. Blank, Kelli Briceño, Cristóbal Castillo Domracheva, Artemio Corrigan, Anne M. Cran, Hugh R. Crawford, Jane T. Cutter, Stephen M. Davis, Eric de Castro, Karina F. De Nardi, Andrigo B. de Vos, Anna P. Delgadillo Keenan, Laura Donelan, Edward M. Espinoza Huerta, Adela R. Faramade, Ibikunle A. Fazil, Mohammed Fotopoulou, Eleni Fruean, Skye N. Gallardo-Arrieta, Fanny Glebova, Olga Gouletsou, Pagona G. Häfelin Manrique, Rodrigo F. Henriques, Joaquim J. G. P. Horta, Rodrigo S. Ignatenko, Natalia Kane, Yaghouba King, Cathy Koenig, Debbie Krupa, Ada Kruzeniski, Steven J. Lanza-Perea, Marta Lazyan, Mihran Lopez Quintana, Adriana M. Losfelt, Thibault Marino, Gabriele Martínez Castañeda, Simón Martínez-López, Mayra F. Masuruli, Bedan M. Meyer, Michael Migneco, Edward J. Nakanwagi, Berna Neal, Karter B. Neunzig, Winifred Nixon, Sally J. Ortega-Pacheco, Antonio Pedraza-Ordoñez, Francisco Peleteiro, Maria C. Polak, Katherine Pye, Ruth J. Ramirez-Ante, Juan C. Reece, John F. Rojas Gutierrez, Jose Sadia, Haleema Schmeling, Sheila K. Shamanova, Olga Sherlock, Alan G. Steenland-Smit, Audrey E. Svitich, Alla Tapia Martínez, Lester J. Thoya Ngoka, Ismail Torres, Cristian G. Tudor, Elizabeth M. van der Wel, Mirjam G. Vițălaru, Bogdan A. Vural, Sevil A. Walkinton, Oliver Wehrle-Martinez, Alvaro S. Widdowson, Sophie A. E. Zvarich, Irina Chinnery, Patrick F. Falkenberg, Maria Gustafsson, Claes M. Murchison, Elizabeth P. |
| author_sort | Strakova, Andrea |
| collection | PubMed |
| description | Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells. |
| format | Online Article Text |
| id | pubmed-7297733 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72977332020-06-22 Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer Strakova, Andrea Nicholls, Thomas J. Baez-Ortega, Adrian Ní Leathlobhair, Máire Sampson, Alexander T. Hughes, Katherine Bolton, Isobelle A. G. Gori, Kevin Wang, Jinhong Airikkala-Otter, Ilona Allen, Janice L. Allum, Karen M. Arnold, Clara L. Bansse-Issa, Leontine Bhutia, Thinlay N. Bisson, Jocelyn L. Blank, Kelli Briceño, Cristóbal Castillo Domracheva, Artemio Corrigan, Anne M. Cran, Hugh R. Crawford, Jane T. Cutter, Stephen M. Davis, Eric de Castro, Karina F. De Nardi, Andrigo B. de Vos, Anna P. Delgadillo Keenan, Laura Donelan, Edward M. Espinoza Huerta, Adela R. Faramade, Ibikunle A. Fazil, Mohammed Fotopoulou, Eleni Fruean, Skye N. Gallardo-Arrieta, Fanny Glebova, Olga Gouletsou, Pagona G. Häfelin Manrique, Rodrigo F. Henriques, Joaquim J. G. P. Horta, Rodrigo S. Ignatenko, Natalia Kane, Yaghouba King, Cathy Koenig, Debbie Krupa, Ada Kruzeniski, Steven J. Lanza-Perea, Marta Lazyan, Mihran Lopez Quintana, Adriana M. Losfelt, Thibault Marino, Gabriele Martínez Castañeda, Simón Martínez-López, Mayra F. Masuruli, Bedan M. Meyer, Michael Migneco, Edward J. Nakanwagi, Berna Neal, Karter B. Neunzig, Winifred Nixon, Sally J. Ortega-Pacheco, Antonio Pedraza-Ordoñez, Francisco Peleteiro, Maria C. Polak, Katherine Pye, Ruth J. Ramirez-Ante, Juan C. Reece, John F. Rojas Gutierrez, Jose Sadia, Haleema Schmeling, Sheila K. Shamanova, Olga Sherlock, Alan G. Steenland-Smit, Audrey E. Svitich, Alla Tapia Martínez, Lester J. Thoya Ngoka, Ismail Torres, Cristian G. Tudor, Elizabeth M. van der Wel, Mirjam G. Vițălaru, Bogdan A. Vural, Sevil A. Walkinton, Oliver Wehrle-Martinez, Alvaro S. Widdowson, Sophie A. E. Zvarich, Irina Chinnery, Patrick F. Falkenberg, Maria Gustafsson, Claes M. Murchison, Elizabeth P. Nat Commun Article Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells. Nature Publishing Group UK 2020-06-16 /pmc/articles/PMC7297733/ /pubmed/32546718 http://dx.doi.org/10.1038/s41467-020-16765-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Strakova, Andrea Nicholls, Thomas J. Baez-Ortega, Adrian Ní Leathlobhair, Máire Sampson, Alexander T. Hughes, Katherine Bolton, Isobelle A. G. Gori, Kevin Wang, Jinhong Airikkala-Otter, Ilona Allen, Janice L. Allum, Karen M. Arnold, Clara L. Bansse-Issa, Leontine Bhutia, Thinlay N. Bisson, Jocelyn L. Blank, Kelli Briceño, Cristóbal Castillo Domracheva, Artemio Corrigan, Anne M. Cran, Hugh R. Crawford, Jane T. Cutter, Stephen M. Davis, Eric de Castro, Karina F. De Nardi, Andrigo B. de Vos, Anna P. Delgadillo Keenan, Laura Donelan, Edward M. Espinoza Huerta, Adela R. Faramade, Ibikunle A. Fazil, Mohammed Fotopoulou, Eleni Fruean, Skye N. Gallardo-Arrieta, Fanny Glebova, Olga Gouletsou, Pagona G. Häfelin Manrique, Rodrigo F. Henriques, Joaquim J. G. P. Horta, Rodrigo S. Ignatenko, Natalia Kane, Yaghouba King, Cathy Koenig, Debbie Krupa, Ada Kruzeniski, Steven J. Lanza-Perea, Marta Lazyan, Mihran Lopez Quintana, Adriana M. Losfelt, Thibault Marino, Gabriele Martínez Castañeda, Simón Martínez-López, Mayra F. Masuruli, Bedan M. Meyer, Michael Migneco, Edward J. Nakanwagi, Berna Neal, Karter B. Neunzig, Winifred Nixon, Sally J. Ortega-Pacheco, Antonio Pedraza-Ordoñez, Francisco Peleteiro, Maria C. Polak, Katherine Pye, Ruth J. Ramirez-Ante, Juan C. Reece, John F. Rojas Gutierrez, Jose Sadia, Haleema Schmeling, Sheila K. Shamanova, Olga Sherlock, Alan G. Steenland-Smit, Audrey E. Svitich, Alla Tapia Martínez, Lester J. Thoya Ngoka, Ismail Torres, Cristian G. Tudor, Elizabeth M. van der Wel, Mirjam G. Vițălaru, Bogdan A. Vural, Sevil A. Walkinton, Oliver Wehrle-Martinez, Alvaro S. Widdowson, Sophie A. E. Zvarich, Irina Chinnery, Patrick F. Falkenberg, Maria Gustafsson, Claes M. Murchison, Elizabeth P. Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title | Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_full | Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_fullStr | Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_full_unstemmed | Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_short | Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_sort | recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297733/ https://www.ncbi.nlm.nih.gov/pubmed/32546718 http://dx.doi.org/10.1038/s41467-020-16765-w |
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