Bax inhibitor-1 deficiency leads to obesity by increasing Ca(2+)-dependent insulin secretion

ABSTRACT: Transmembrane BAX inhibitor motif containing 6 (TMBIM6), also known as Bax inhibitor-1, is an evolutionarily conserved protein involved in endoplasmic reticulum (ER) function. TMBIM6 is an ER Ca(2+) leak channel and its deficiency enhances susceptibility to ER stress due to inhibition of t...

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Detalles Bibliográficos
Autores principales: Philippaert, Koenraad, Roden, Michael, Lisak, Dmitrij, Bueno, Diones, Jelenik, Tomas, Radyushkin, Konstantin, Schacht, Teresa, Mesuere, Margot, Wüllner, Verena, Herrmann, Ann-Kathrin, Baumgart, Jan, Vennekens, Rudi, Methner, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297831/
https://www.ncbi.nlm.nih.gov/pubmed/32394396
http://dx.doi.org/10.1007/s00109-020-01914-x

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