BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury

Acetaminophen (APAP) induced hepatotoxicity involves activation of c-Jun amino-terminal kinase (JNK), mitochondrial damage and ER stress. BGP-15, a hydroximic acid derivative, has been reported to have hepatoprotective effects in APAP overdose induced liver damage. Effect of BGP-15 was further inves...

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Autores principales: Sarnyai, Farkas, Szekerczés, Timea, Csala, Miklós, Sümegi, Balázs, Szarka, András, Schaff, Zsuzsa, Mandl, József
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297855/
https://www.ncbi.nlm.nih.gov/pubmed/31705481
http://dx.doi.org/10.1007/s12253-019-00721-1
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author Sarnyai, Farkas
Szekerczés, Timea
Csala, Miklós
Sümegi, Balázs
Szarka, András
Schaff, Zsuzsa
Mandl, József
author_facet Sarnyai, Farkas
Szekerczés, Timea
Csala, Miklós
Sümegi, Balázs
Szarka, András
Schaff, Zsuzsa
Mandl, József
author_sort Sarnyai, Farkas
collection PubMed
description Acetaminophen (APAP) induced hepatotoxicity involves activation of c-Jun amino-terminal kinase (JNK), mitochondrial damage and ER stress. BGP-15, a hydroximic acid derivative, has been reported to have hepatoprotective effects in APAP overdose induced liver damage. Effect of BGP-15 was further investigated on mitochondria in APAP-overdose induced acute liver injury in mice. We found that BGP-15 efficiently preserved mitochondrial morphology, and it caused a marked decrease in the number of damaged mitochondria. Attenuation of mitochondrial damage by BGP-15 is supported by immunohistochemistry as the TOMM20 label and the co-localized autophagy markers detected in the livers of APAP-treated mice were markedly reduced upon BGP-15 administration. This effect, along with the observed prevention of JNK activation likely contribute to the mitochondrial protective action of BGP-15.
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spelling pubmed-72978552020-06-19 BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury Sarnyai, Farkas Szekerczés, Timea Csala, Miklós Sümegi, Balázs Szarka, András Schaff, Zsuzsa Mandl, József Pathol Oncol Res Original Article Acetaminophen (APAP) induced hepatotoxicity involves activation of c-Jun amino-terminal kinase (JNK), mitochondrial damage and ER stress. BGP-15, a hydroximic acid derivative, has been reported to have hepatoprotective effects in APAP overdose induced liver damage. Effect of BGP-15 was further investigated on mitochondria in APAP-overdose induced acute liver injury in mice. We found that BGP-15 efficiently preserved mitochondrial morphology, and it caused a marked decrease in the number of damaged mitochondria. Attenuation of mitochondrial damage by BGP-15 is supported by immunohistochemistry as the TOMM20 label and the co-localized autophagy markers detected in the livers of APAP-treated mice were markedly reduced upon BGP-15 administration. This effect, along with the observed prevention of JNK activation likely contribute to the mitochondrial protective action of BGP-15. Springer Netherlands 2019-11-08 2020 /pmc/articles/PMC7297855/ /pubmed/31705481 http://dx.doi.org/10.1007/s12253-019-00721-1 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Sarnyai, Farkas
Szekerczés, Timea
Csala, Miklós
Sümegi, Balázs
Szarka, András
Schaff, Zsuzsa
Mandl, József
BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury
title BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury
title_full BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury
title_fullStr BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury
title_full_unstemmed BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury
title_short BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury
title_sort bgp-15 protects mitochondria in acute, acetaminophen overdose induced liver injury
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297855/
https://www.ncbi.nlm.nih.gov/pubmed/31705481
http://dx.doi.org/10.1007/s12253-019-00721-1
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