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Polycystic Ovary Syndrome and Psychotic Disorder
Polycystic ovary syndrome (PCOS), a disease that usually emerges during adolescence, is characterized by hormonal imbalance and ovarian dysfunction. The prevalence can vary between 5.6 to 21.3% in women and 6% in adolescent girls. This discrepancy is related to the population studied and the diagnos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297942/ https://www.ncbi.nlm.nih.gov/pubmed/32587538 http://dx.doi.org/10.3389/fpsyt.2020.00543 |
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author | Doretto, Larissa Mari, Flora Chaves Chaves, Ana Cristina |
author_facet | Doretto, Larissa Mari, Flora Chaves Chaves, Ana Cristina |
author_sort | Doretto, Larissa |
collection | PubMed |
description | Polycystic ovary syndrome (PCOS), a disease that usually emerges during adolescence, is characterized by hormonal imbalance and ovarian dysfunction. The prevalence can vary between 5.6 to 21.3% in women and 6% in adolescent girls. This discrepancy is related to the population studied and the diagnostic criteria used. The underlying pathophysiology of PCOS is not fully understood, but it can lead to a number of co-morbidities, including hypertension, diabetes, dyslipidemia, and also, mental health disorders. Clinical and preclinical data indicate neuroendocrine involvement with dysfunction in gamma-Aminobutyric acid (GABA) signaling and neuronal androgen receptors that might reduce hypothalamic sensitivity and lead to an impairment of estradiol and progesterone feedback. Based on these assumptions, the aims of this paper are to review the association of PCOS and psychotic disorders in order to address the burden of women comorbid for both conditions. |
format | Online Article Text |
id | pubmed-7297942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72979422020-06-24 Polycystic Ovary Syndrome and Psychotic Disorder Doretto, Larissa Mari, Flora Chaves Chaves, Ana Cristina Front Psychiatry Psychiatry Polycystic ovary syndrome (PCOS), a disease that usually emerges during adolescence, is characterized by hormonal imbalance and ovarian dysfunction. The prevalence can vary between 5.6 to 21.3% in women and 6% in adolescent girls. This discrepancy is related to the population studied and the diagnostic criteria used. The underlying pathophysiology of PCOS is not fully understood, but it can lead to a number of co-morbidities, including hypertension, diabetes, dyslipidemia, and also, mental health disorders. Clinical and preclinical data indicate neuroendocrine involvement with dysfunction in gamma-Aminobutyric acid (GABA) signaling and neuronal androgen receptors that might reduce hypothalamic sensitivity and lead to an impairment of estradiol and progesterone feedback. Based on these assumptions, the aims of this paper are to review the association of PCOS and psychotic disorders in order to address the burden of women comorbid for both conditions. Frontiers Media S.A. 2020-06-10 /pmc/articles/PMC7297942/ /pubmed/32587538 http://dx.doi.org/10.3389/fpsyt.2020.00543 Text en Copyright © 2020 Doretto, Mari and Chaves http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Doretto, Larissa Mari, Flora Chaves Chaves, Ana Cristina Polycystic Ovary Syndrome and Psychotic Disorder |
title | Polycystic Ovary Syndrome and Psychotic Disorder |
title_full | Polycystic Ovary Syndrome and Psychotic Disorder |
title_fullStr | Polycystic Ovary Syndrome and Psychotic Disorder |
title_full_unstemmed | Polycystic Ovary Syndrome and Psychotic Disorder |
title_short | Polycystic Ovary Syndrome and Psychotic Disorder |
title_sort | polycystic ovary syndrome and psychotic disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297942/ https://www.ncbi.nlm.nih.gov/pubmed/32587538 http://dx.doi.org/10.3389/fpsyt.2020.00543 |
work_keys_str_mv | AT dorettolarissa polycysticovarysyndromeandpsychoticdisorder AT mariflorachaves polycysticovarysyndromeandpsychoticdisorder AT chavesanacristina polycysticovarysyndromeandpsychoticdisorder |