Mutations in the C1 element of the insulin promoter lead to diabetic phenotypes in homozygous mice

Genome editing technologies such as CRISPR–Cas9 are widely used to establish causal associations between mutations and phenotypes. However, CRISPR–Cas9 is rarely used to analyze promoter regions. The insulin promoter region (approximately 1,000 bp) directs β cell-specific expression of insulin, whic...

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Detalles Bibliográficos
Autores principales: Noguchi, Hirofumi, Miyagi-Shiohira, Chika, Nakashima, Yoshiki, Kinjo, Takao, Saitoh, Issei, Watanabe, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297962/
https://www.ncbi.nlm.nih.gov/pubmed/32546815
http://dx.doi.org/10.1038/s42003-020-1040-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297962/
https://www.ncbi.nlm.nih.gov/pubmed/32546815
http://dx.doi.org/10.1038/s42003-020-1040-z

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