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Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
Recent studies combine two novel technologies, single-cell RNA-sequencing and CRISPR-Cas9 barcode editing for elucidating developmental lineages at the whole organism level. While these studies provided several insights, they face several computational challenges. First, lineages are reconstructed b...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298005/ https://www.ncbi.nlm.nih.gov/pubmed/32546686 http://dx.doi.org/10.1038/s41467-020-16821-5 |