Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors

Subsets of breast tumors present major clinical challenges, including triple-negative, metastatic/recurrent disease and rare histologies. Here, we developed 37 patient-derived xenografts (PDX) from these difficult-to-treat cancers to interrogate their molecular composition and functional biology. Wh...

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Detalles Bibliográficos
Autores principales: Savage, Paul, Pacis, Alain, Kuasne, Hellen, Liu, Leah, Lai, Daniel, Wan, Adrian, Dankner, Matthew, Martinez, Constanza, Muñoz-Ramos, Valentina, Pilon, Virginie, Monast, Anie, Zhao, Hong, Souleimanova, Margarita, Annis, Matthew G., Aguilar-Mahecha, Adriana, Lafleur, Josiane, Bertos, Nicholas R., Asselah, Jamil, Bouganim, Nathaniel, Petrecca, Kevin, Siegel, Peter M., Omeroglu, Atilla, Shah, Sohrab P., Aparicio, Samuel, Basik, Mark, Meterissian, Sarkis, Park, Morag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298048/
https://www.ncbi.nlm.nih.gov/pubmed/32546838
http://dx.doi.org/10.1038/s42003-020-1042-x

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