Single AAV-Mediated CRISPR-SaCas9 Inhibits HSV-1 Replication by Editing ICP4 in Trigeminal Ganglion Neurons

Herpes simplex keratitis (HSK) is the most common cause of corneal blindness in developed nations, caused by primary or recurrent herpes simplex virus 1 (HSV-1) infection of the cornea. Latent infection of HSV-1, especially in the trigeminal ganglion (TG), causes recurrence of HSV-1 infection. As an...

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Detalles Bibliográficos
Autores principales: Chen, Yuxi, Zhi, Shengyao, Liang, Puping, Zheng, Qi, Liu, Mengni, Zhao, Qi, Ren, Jian, Cui, Jun, Huang, Junjiu, Liu, Yizhi, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298336/
https://www.ncbi.nlm.nih.gov/pubmed/32577430
http://dx.doi.org/10.1016/j.omtm.2020.05.011

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