Redox States of Protein Cysteines in Pathways of Protein Turnover and Cytoskeleton Dynamics Are Changed with Aging and Reversed by Slc7a11 Restoration in Mouse Lung Fibroblasts

Slc7a11 is the key component of system X(c)(−), an antiporter that imports cystine (CySS) and exports glutamate. It plays an important role in cellular defense against oxidative stress because cysteine (Cys), reduced from CySS, is used for and limits the synthesis of glutathione (GSH). We have shown...

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Detalles Bibliográficos
Autores principales: Zheng, Yuxuan, Merchant, Michael L., Burke, Tom J., Ritzenthaler, Jeffrey D., Li, Ming, Gaweda, Adam E., Benz, Frederick W., Roman, Jesse, Watson, Walter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298344/
https://www.ncbi.nlm.nih.gov/pubmed/32587657
http://dx.doi.org/10.1155/2020/2468986

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