Cargando…
NeoCoV Is Closer to MERS-CoV than SARS-CoV
Recently, Coronavirus has been given considerable attention from the biomedical community based on the emergence and isolation of a deadly coronavirus infecting human. To understand the behavior of the newly emerging MERS-CoV requires knowledge at different levels (epidemiologic, antigenic, and path...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298434/ https://www.ncbi.nlm.nih.gov/pubmed/32595278 http://dx.doi.org/10.1177/1178633720930711 |
_version_ | 1783547204404772864 |
---|---|
author | Hassan, Mohamed M Hussain, Mohamed A Kambal, Sumaya Elshikh, Ahmed A Gendeel, Osama R Ahmed, Siddig A Altayeb, Rami A Muhajir, Abdelhafiz MA Mohamed, Sofia B |
author_facet | Hassan, Mohamed M Hussain, Mohamed A Kambal, Sumaya Elshikh, Ahmed A Gendeel, Osama R Ahmed, Siddig A Altayeb, Rami A Muhajir, Abdelhafiz MA Mohamed, Sofia B |
author_sort | Hassan, Mohamed M |
collection | PubMed |
description | Recently, Coronavirus has been given considerable attention from the biomedical community based on the emergence and isolation of a deadly coronavirus infecting human. To understand the behavior of the newly emerging MERS-CoV requires knowledge at different levels (epidemiologic, antigenic, and pathogenic), and this knowledge can be generated from the most related viruses. In this study, we aimed to compare between 3 species of Coronavirus, namely Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome (SARS-CoV), and NeoCoV regarding whole genomes and 6 similar proteins (E, M, N, S, ORF1a, and ORF1ab) using different bioinformatics tools to provide a better understanding of the relationship between the 3 viruses at the nucleotide and amino acids levels. All sequences have been retrieved from National Center for Biotechnology Information (NCBI). Regards to target genomes’ phylogenetic analysis showed that MERS and SARS-CoVs were closer to each other compared with NeoCoV, and the last has the longest relative time. We found that all phylogenetic methods in addition to all parameters (physical and chemical properties of amino acids such as the number of amino acid, molecular weight, atomic composition, theoretical pI, and structural formula) indicated that NeoCoV proteins were the most related to MERS-CoV one. All phylogenetic trees (by both maximum-likelihood and neighbor-joining methods) indicated that NeoCoV proteins have less evolutionary changes except for ORF1a by just maximum-likelihood method. Our results indicated high similarity between viral structural proteins which are responsible for viral infectivity; therefore, we expect that NeoCoV sooner may appear in human-related infection. |
format | Online Article Text |
id | pubmed-7298434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-72984342020-06-25 NeoCoV Is Closer to MERS-CoV than SARS-CoV Hassan, Mohamed M Hussain, Mohamed A Kambal, Sumaya Elshikh, Ahmed A Gendeel, Osama R Ahmed, Siddig A Altayeb, Rami A Muhajir, Abdelhafiz MA Mohamed, Sofia B Infect Dis (Auckl) Original Research Recently, Coronavirus has been given considerable attention from the biomedical community based on the emergence and isolation of a deadly coronavirus infecting human. To understand the behavior of the newly emerging MERS-CoV requires knowledge at different levels (epidemiologic, antigenic, and pathogenic), and this knowledge can be generated from the most related viruses. In this study, we aimed to compare between 3 species of Coronavirus, namely Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome (SARS-CoV), and NeoCoV regarding whole genomes and 6 similar proteins (E, M, N, S, ORF1a, and ORF1ab) using different bioinformatics tools to provide a better understanding of the relationship between the 3 viruses at the nucleotide and amino acids levels. All sequences have been retrieved from National Center for Biotechnology Information (NCBI). Regards to target genomes’ phylogenetic analysis showed that MERS and SARS-CoVs were closer to each other compared with NeoCoV, and the last has the longest relative time. We found that all phylogenetic methods in addition to all parameters (physical and chemical properties of amino acids such as the number of amino acid, molecular weight, atomic composition, theoretical pI, and structural formula) indicated that NeoCoV proteins were the most related to MERS-CoV one. All phylogenetic trees (by both maximum-likelihood and neighbor-joining methods) indicated that NeoCoV proteins have less evolutionary changes except for ORF1a by just maximum-likelihood method. Our results indicated high similarity between viral structural proteins which are responsible for viral infectivity; therefore, we expect that NeoCoV sooner may appear in human-related infection. SAGE Publications 2020-06-16 /pmc/articles/PMC7298434/ /pubmed/32595278 http://dx.doi.org/10.1177/1178633720930711 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Hassan, Mohamed M Hussain, Mohamed A Kambal, Sumaya Elshikh, Ahmed A Gendeel, Osama R Ahmed, Siddig A Altayeb, Rami A Muhajir, Abdelhafiz MA Mohamed, Sofia B NeoCoV Is Closer to MERS-CoV than SARS-CoV |
title | NeoCoV Is Closer to MERS-CoV than SARS-CoV |
title_full | NeoCoV Is Closer to MERS-CoV than SARS-CoV |
title_fullStr | NeoCoV Is Closer to MERS-CoV than SARS-CoV |
title_full_unstemmed | NeoCoV Is Closer to MERS-CoV than SARS-CoV |
title_short | NeoCoV Is Closer to MERS-CoV than SARS-CoV |
title_sort | neocov is closer to mers-cov than sars-cov |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298434/ https://www.ncbi.nlm.nih.gov/pubmed/32595278 http://dx.doi.org/10.1177/1178633720930711 |
work_keys_str_mv | AT hassanmohamedm neocovisclosertomerscovthansarscov AT hussainmohameda neocovisclosertomerscovthansarscov AT kambalsumaya neocovisclosertomerscovthansarscov AT elshikhahmeda neocovisclosertomerscovthansarscov AT gendeelosamar neocovisclosertomerscovthansarscov AT ahmedsiddiga neocovisclosertomerscovthansarscov AT altayebramia neocovisclosertomerscovthansarscov AT muhajirabdelhafizma neocovisclosertomerscovthansarscov AT mohamedsofiab neocovisclosertomerscovthansarscov |