Cargando…

Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil

BACKGROUND: Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson’s disease (PD) and may influence the progression of the disease. However, the evidence regarding the impact of pesticide exposure on mortality among patients with PD is equiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider Medeiros, Márcio, P. Reddy, Sumanth, P. Socal, Mariana, Schumacher-Schuh, Artur Francisco, Mello Rieder, Carlos Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298782/
https://www.ncbi.nlm.nih.gov/pubmed/32552814
http://dx.doi.org/10.1186/s12940-020-00624-8
_version_ 1783547270447235072
author Schneider Medeiros, Márcio
P. Reddy, Sumanth
P. Socal, Mariana
Schumacher-Schuh, Artur Francisco
Mello Rieder, Carlos Roberto
author_facet Schneider Medeiros, Márcio
P. Reddy, Sumanth
P. Socal, Mariana
Schumacher-Schuh, Artur Francisco
Mello Rieder, Carlos Roberto
author_sort Schneider Medeiros, Márcio
collection PubMed
description BACKGROUND: Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson’s disease (PD) and may influence the progression of the disease. However, the evidence regarding the impact of pesticide exposure on mortality among patients with PD is equivocal. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil. METHODS: A total of 150 patients with idiopathic PD were enrolled from 2008 to 2013 and followed until 2019. In addition to undergoing a detailed neurologic evaluation, patients completed surveys regarding socioeconomic status and environmental exposures. RESULTS: Twenty patients (13.3%) reported a history of occupational pesticide exposure with a median duration of exposure of 10 years (mean = 13.1, SD = 11.2). Patients with a history of occupational pesticide exposure had higher UPDRS-III scores, though there were no significant differences in regards to age, sex, disease duration, Charlson Comorbidity Index, and age at symptom onset. Patients with occupational pesticide exposure were more than twice as likely to die than their unexposed PD counterparts (HR = 2.32, 95% CI [1.15, 4.66], p = 0.018). Occupational pesticide exposure was also a significant predictor of death in a cox-proportional hazards model which included smoking and caffeine intake history (HR = 2.23, 95% CI [1.09, 4.59], p = 0.03)) and another which included several measures of socioeconomic status (HR = 3.91, 95% CI [1.32, 11.58], p = 0.01). CONCLUSION: In this prospective cohort study, we found an increased all-cause mortality risk in PD patients with occupational exposure to pesticides. More studies are needed to further analyze this topic with longer follow-up periods, more detailed exposure information, and more specific causes of mortality.
format Online
Article
Text
id pubmed-7298782
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-72987822020-06-17 Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil Schneider Medeiros, Márcio P. Reddy, Sumanth P. Socal, Mariana Schumacher-Schuh, Artur Francisco Mello Rieder, Carlos Roberto Environ Health Research BACKGROUND: Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson’s disease (PD) and may influence the progression of the disease. However, the evidence regarding the impact of pesticide exposure on mortality among patients with PD is equivocal. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil. METHODS: A total of 150 patients with idiopathic PD were enrolled from 2008 to 2013 and followed until 2019. In addition to undergoing a detailed neurologic evaluation, patients completed surveys regarding socioeconomic status and environmental exposures. RESULTS: Twenty patients (13.3%) reported a history of occupational pesticide exposure with a median duration of exposure of 10 years (mean = 13.1, SD = 11.2). Patients with a history of occupational pesticide exposure had higher UPDRS-III scores, though there were no significant differences in regards to age, sex, disease duration, Charlson Comorbidity Index, and age at symptom onset. Patients with occupational pesticide exposure were more than twice as likely to die than their unexposed PD counterparts (HR = 2.32, 95% CI [1.15, 4.66], p = 0.018). Occupational pesticide exposure was also a significant predictor of death in a cox-proportional hazards model which included smoking and caffeine intake history (HR = 2.23, 95% CI [1.09, 4.59], p = 0.03)) and another which included several measures of socioeconomic status (HR = 3.91, 95% CI [1.32, 11.58], p = 0.01). CONCLUSION: In this prospective cohort study, we found an increased all-cause mortality risk in PD patients with occupational exposure to pesticides. More studies are needed to further analyze this topic with longer follow-up periods, more detailed exposure information, and more specific causes of mortality. BioMed Central 2020-06-17 /pmc/articles/PMC7298782/ /pubmed/32552814 http://dx.doi.org/10.1186/s12940-020-00624-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Schneider Medeiros, Márcio
P. Reddy, Sumanth
P. Socal, Mariana
Schumacher-Schuh, Artur Francisco
Mello Rieder, Carlos Roberto
Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil
title Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil
title_full Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil
title_fullStr Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil
title_full_unstemmed Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil
title_short Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil
title_sort occupational pesticide exposure and the risk of death in patients with parkinson’s disease: an observational study in southern brazil
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298782/
https://www.ncbi.nlm.nih.gov/pubmed/32552814
http://dx.doi.org/10.1186/s12940-020-00624-8
work_keys_str_mv AT schneidermedeirosmarcio occupationalpesticideexposureandtheriskofdeathinpatientswithparkinsonsdiseaseanobservationalstudyinsouthernbrazil
AT preddysumanth occupationalpesticideexposureandtheriskofdeathinpatientswithparkinsonsdiseaseanobservationalstudyinsouthernbrazil
AT psocalmariana occupationalpesticideexposureandtheriskofdeathinpatientswithparkinsonsdiseaseanobservationalstudyinsouthernbrazil
AT schumacherschuharturfrancisco occupationalpesticideexposureandtheriskofdeathinpatientswithparkinsonsdiseaseanobservationalstudyinsouthernbrazil
AT melloriedercarlosroberto occupationalpesticideexposureandtheriskofdeathinpatientswithparkinsonsdiseaseanobservationalstudyinsouthernbrazil