Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma

BACKGROUND: Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disease. Some children with OMS also have neuroblastoma (NB). We and others have previously documented that serum IgG from children with OMS and NB induces neuronal cytolysis and activates several signaling pathways. However, the...

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Detalles Bibliográficos
Autores principales: Ding, Xu, Yang, Wei, Ren, Qinghua, Hu, Jiajian, Yang, Shen, Han, Wei, Wang, Jing, Wang, Xu, Wang, Huanmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298801/
https://www.ncbi.nlm.nih.gov/pubmed/32546235
http://dx.doi.org/10.1186/s12974-020-01839-9

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