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Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to (18)F-FDG PET/CT

PURPOSE: Evaluate the feasibility of fluorine-18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging in patients with gastric cancer by optimizing the scan protocol and to compare the image quality to (18)F FDG PET and computed tomography (CT). MET...

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Autores principales: Zheng, Dong, Liu, Yi, Liu, Jiajin, Li, Ke, Lin, Mu, Schmidt, Holger, Xu, Baixuan, Tian, Jiahe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298805/
https://www.ncbi.nlm.nih.gov/pubmed/32546207
http://dx.doi.org/10.1186/s40644-020-00317-y
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author Zheng, Dong
Liu, Yi
Liu, Jiajin
Li, Ke
Lin, Mu
Schmidt, Holger
Xu, Baixuan
Tian, Jiahe
author_facet Zheng, Dong
Liu, Yi
Liu, Jiajin
Li, Ke
Lin, Mu
Schmidt, Holger
Xu, Baixuan
Tian, Jiahe
author_sort Zheng, Dong
collection PubMed
description PURPOSE: Evaluate the feasibility of fluorine-18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging in patients with gastric cancer by optimizing the scan protocol and to compare the image quality to (18)F FDG PET and computed tomography (CT). METHODS: The PET/CT and PET/MR imaging were sequentially performed in 30 patients with gastric cancer diagnosed by gastroscope using a single-injection-with-dual-imaging protocol. After intravenous injection of (18)F-FDG (mean, 249 MBq), PET/CT imaging including low-dose CT was performed (mean uptake time, 47 ± 6 min), and PET/MR imaging including a T1-weighted Dixon sequence for attenuation correction and two different T2-weighted sequences was subsequently acquired (88 ± 15 min after (18)F-FDG injection). Four series of images (CT from PET/CT, T1W, T2W Half-Fourier acquisition single-shot turbo spin-echo [T2W-HASTE] and T2W-BLADE from PET/MR) were visually evaluated using a 3–4 points scale for: (1) image artifacts, (2) lesion conspicuity and (3) image fusion quality. The characteristics of the primary lesions were assessed and compared between the PET/CT and PET/MR acquisitions. RESULTS: The image quality and lesion conspicuity of the T2W-HASTE images were significantly improved compared to that of the T2W-BLADE images. A significantly higher number of artifacts were seen in the T2W-HASTE images compared with the T1W and CT images (p < 0. 05). No differences in the accuracy of image fusion between PET/MR and PET/CT (p > 0. 05); however, significant difference was seen in the lesion conspicuity measurements (p < 0.05) with T2W-HASTE being superior. For information about the primary lesion characteristics, the T2W-HASTE images provided the most successful identifications compared with those of the T1W and PET/CT (13vs7vs5) images. CONCLUSIONS: PET/MR with the T2W-HASTE was better at revealing the details of local stomach lesions compared with PET/CT imaging. Combining the PET/MR with the T2W-HASTE technique is a promising imaging method for diagnosing and staging gastric cancer.
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spelling pubmed-72988052020-06-17 Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to (18)F-FDG PET/CT Zheng, Dong Liu, Yi Liu, Jiajin Li, Ke Lin, Mu Schmidt, Holger Xu, Baixuan Tian, Jiahe Cancer Imaging Research Article PURPOSE: Evaluate the feasibility of fluorine-18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging in patients with gastric cancer by optimizing the scan protocol and to compare the image quality to (18)F FDG PET and computed tomography (CT). METHODS: The PET/CT and PET/MR imaging were sequentially performed in 30 patients with gastric cancer diagnosed by gastroscope using a single-injection-with-dual-imaging protocol. After intravenous injection of (18)F-FDG (mean, 249 MBq), PET/CT imaging including low-dose CT was performed (mean uptake time, 47 ± 6 min), and PET/MR imaging including a T1-weighted Dixon sequence for attenuation correction and two different T2-weighted sequences was subsequently acquired (88 ± 15 min after (18)F-FDG injection). Four series of images (CT from PET/CT, T1W, T2W Half-Fourier acquisition single-shot turbo spin-echo [T2W-HASTE] and T2W-BLADE from PET/MR) were visually evaluated using a 3–4 points scale for: (1) image artifacts, (2) lesion conspicuity and (3) image fusion quality. The characteristics of the primary lesions were assessed and compared between the PET/CT and PET/MR acquisitions. RESULTS: The image quality and lesion conspicuity of the T2W-HASTE images were significantly improved compared to that of the T2W-BLADE images. A significantly higher number of artifacts were seen in the T2W-HASTE images compared with the T1W and CT images (p < 0. 05). No differences in the accuracy of image fusion between PET/MR and PET/CT (p > 0. 05); however, significant difference was seen in the lesion conspicuity measurements (p < 0.05) with T2W-HASTE being superior. For information about the primary lesion characteristics, the T2W-HASTE images provided the most successful identifications compared with those of the T1W and PET/CT (13vs7vs5) images. CONCLUSIONS: PET/MR with the T2W-HASTE was better at revealing the details of local stomach lesions compared with PET/CT imaging. Combining the PET/MR with the T2W-HASTE technique is a promising imaging method for diagnosing and staging gastric cancer. BioMed Central 2020-06-16 /pmc/articles/PMC7298805/ /pubmed/32546207 http://dx.doi.org/10.1186/s40644-020-00317-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zheng, Dong
Liu, Yi
Liu, Jiajin
Li, Ke
Lin, Mu
Schmidt, Holger
Xu, Baixuan
Tian, Jiahe
Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to (18)F-FDG PET/CT
title Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to (18)F-FDG PET/CT
title_full Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to (18)F-FDG PET/CT
title_fullStr Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to (18)F-FDG PET/CT
title_full_unstemmed Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to (18)F-FDG PET/CT
title_short Improving MR sequence of 18F-FDG PET/MR for diagnosing and staging gastric Cancer: a comparison study to (18)F-FDG PET/CT
title_sort improving mr sequence of 18f-fdg pet/mr for diagnosing and staging gastric cancer: a comparison study to (18)f-fdg pet/ct
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298805/
https://www.ncbi.nlm.nih.gov/pubmed/32546207
http://dx.doi.org/10.1186/s40644-020-00317-y
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