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25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

BACKGROUND: Genome-wide association studies of Alzheimer’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators of neuroinflammation in AD remain poorly understood. The oxysterol 25-hydroxycho...

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Detalles Bibliográficos
Autores principales:	Wong, Man Ying, Lewis, Michael, Doherty, James J., Shi, Yang, Cashikar, Anil G., Amelianchik, Anna, Tymchuk, Svitlana, Sullivan, Patrick M., Qian, Mingxing, Covey, Douglas F., Petsko, Gregory A., Holtzman, David M., Paul, Steven M., Luo, Wenjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298825/ https://www.ncbi.nlm.nih.gov/pubmed/32552741 http://dx.doi.org/10.1186/s12974-020-01869-3

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