The Binge Eating Genetics Initiative (BEGIN): study protocol

BACKGROUND: The Binge Eating Genetics Initiative (BEGIN) is a multipronged investigation examining the interplay of genomic, gut microbiota, and behavioral factors in bulimia nervosa and binge-eating disorder. METHODS: 1000 individuals who meet current diagnostic criteria for bulimia nervosa or bing...

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Autores principales: Bulik, Cynthia M., Butner, Jonathan E., Tregarthen, Jenna, Thornton, Laura M., Flatt, Rachael E., Smith, Tosha, Carroll, Ian M., Baucom, Brian R.W., Deboeck, Pascal R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298834/
https://www.ncbi.nlm.nih.gov/pubmed/32546136
http://dx.doi.org/10.1186/s12888-020-02698-7
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author Bulik, Cynthia M.
Butner, Jonathan E.
Tregarthen, Jenna
Thornton, Laura M.
Flatt, Rachael E.
Smith, Tosha
Carroll, Ian M.
Baucom, Brian R.W.
Deboeck, Pascal R.
author_facet Bulik, Cynthia M.
Butner, Jonathan E.
Tregarthen, Jenna
Thornton, Laura M.
Flatt, Rachael E.
Smith, Tosha
Carroll, Ian M.
Baucom, Brian R.W.
Deboeck, Pascal R.
author_sort Bulik, Cynthia M.
collection PubMed
description BACKGROUND: The Binge Eating Genetics Initiative (BEGIN) is a multipronged investigation examining the interplay of genomic, gut microbiota, and behavioral factors in bulimia nervosa and binge-eating disorder. METHODS: 1000 individuals who meet current diagnostic criteria for bulimia nervosa or binge-eating disorder are being recruited to collect saliva samples for genotyping, fecal sampling for microbiota characterization, and recording of 30 days of passive data and behavioral phenotyping related to eating disorders using the app Recovery Record adapted for the Apple Watch. DISCUSSION: BEGIN examines the interplay of genomic, gut microbiota, and behavioral factors to explore etiology and develop predictors of risk, course of illness, and response to treatment in bulimia nervosa and binge-eating disorder. We will optimize the richness and longitudinal structure of deep passive and active phenotypic data to lay the foundation for a personalized precision medicine approach enabling just-in-time interventions that will allow individuals to disrupt eating disorder behaviors in real time before they occur. TRIAL REGISTRATION: The ClinicalTrials.gov identifier is NCT04162574. November 14, 2019, Retrospectively Registered.
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spelling pubmed-72988342020-06-17 The Binge Eating Genetics Initiative (BEGIN): study protocol Bulik, Cynthia M. Butner, Jonathan E. Tregarthen, Jenna Thornton, Laura M. Flatt, Rachael E. Smith, Tosha Carroll, Ian M. Baucom, Brian R.W. Deboeck, Pascal R. BMC Psychiatry Study Protocol BACKGROUND: The Binge Eating Genetics Initiative (BEGIN) is a multipronged investigation examining the interplay of genomic, gut microbiota, and behavioral factors in bulimia nervosa and binge-eating disorder. METHODS: 1000 individuals who meet current diagnostic criteria for bulimia nervosa or binge-eating disorder are being recruited to collect saliva samples for genotyping, fecal sampling for microbiota characterization, and recording of 30 days of passive data and behavioral phenotyping related to eating disorders using the app Recovery Record adapted for the Apple Watch. DISCUSSION: BEGIN examines the interplay of genomic, gut microbiota, and behavioral factors to explore etiology and develop predictors of risk, course of illness, and response to treatment in bulimia nervosa and binge-eating disorder. We will optimize the richness and longitudinal structure of deep passive and active phenotypic data to lay the foundation for a personalized precision medicine approach enabling just-in-time interventions that will allow individuals to disrupt eating disorder behaviors in real time before they occur. TRIAL REGISTRATION: The ClinicalTrials.gov identifier is NCT04162574. November 14, 2019, Retrospectively Registered. BioMed Central 2020-06-16 /pmc/articles/PMC7298834/ /pubmed/32546136 http://dx.doi.org/10.1186/s12888-020-02698-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Study Protocol
Bulik, Cynthia M.
Butner, Jonathan E.
Tregarthen, Jenna
Thornton, Laura M.
Flatt, Rachael E.
Smith, Tosha
Carroll, Ian M.
Baucom, Brian R.W.
Deboeck, Pascal R.
The Binge Eating Genetics Initiative (BEGIN): study protocol
title The Binge Eating Genetics Initiative (BEGIN): study protocol
title_full The Binge Eating Genetics Initiative (BEGIN): study protocol
title_fullStr The Binge Eating Genetics Initiative (BEGIN): study protocol
title_full_unstemmed The Binge Eating Genetics Initiative (BEGIN): study protocol
title_short The Binge Eating Genetics Initiative (BEGIN): study protocol
title_sort binge eating genetics initiative (begin): study protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298834/
https://www.ncbi.nlm.nih.gov/pubmed/32546136
http://dx.doi.org/10.1186/s12888-020-02698-7
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