Hepatitis in children with tuberculosis: a case report and review of the literature

BACKGROUND: Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment. CASE PRESENTATION: We report an antibiotic naïve 13-month-old male from Nepal with pulmonary...

Descripción completa

Detalles Bibliográficos
Autores principales: Sanchez-Codez, Maria, Hunt, W. Garret, Watson, Joshua, Mejias, Asuncion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298953/
https://www.ncbi.nlm.nih.gov/pubmed/32546255
http://dx.doi.org/10.1186/s12890-020-01215-6
_version_ 1783547304681144320
author Sanchez-Codez, Maria
Hunt, W. Garret
Watson, Joshua
Mejias, Asuncion
author_facet Sanchez-Codez, Maria
Hunt, W. Garret
Watson, Joshua
Mejias, Asuncion
author_sort Sanchez-Codez, Maria
collection PubMed
description BACKGROUND: Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment. CASE PRESENTATION: We report an antibiotic naïve 13-month-old male from Nepal with pulmonary TB and hepatitis, who improved after TB treatment. We also performed a literature review for TB-associated hepatitis in children. CONCLUSIONS: Liver function tests should be considered, when feasible, in infants and young children with pulmonary TB. Testing could help to identify and manage patients with TB-associated hepatic abnormalities, and also to establish a baseline for detection and management of liver injury associated with anti-TB therapy.
format Online
Article
Text
id pubmed-7298953
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-72989532020-06-18 Hepatitis in children with tuberculosis: a case report and review of the literature Sanchez-Codez, Maria Hunt, W. Garret Watson, Joshua Mejias, Asuncion BMC Pulm Med Case Report BACKGROUND: Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment. CASE PRESENTATION: We report an antibiotic naïve 13-month-old male from Nepal with pulmonary TB and hepatitis, who improved after TB treatment. We also performed a literature review for TB-associated hepatitis in children. CONCLUSIONS: Liver function tests should be considered, when feasible, in infants and young children with pulmonary TB. Testing could help to identify and manage patients with TB-associated hepatic abnormalities, and also to establish a baseline for detection and management of liver injury associated with anti-TB therapy. BioMed Central 2020-06-16 /pmc/articles/PMC7298953/ /pubmed/32546255 http://dx.doi.org/10.1186/s12890-020-01215-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Sanchez-Codez, Maria
Hunt, W. Garret
Watson, Joshua
Mejias, Asuncion
Hepatitis in children with tuberculosis: a case report and review of the literature
title Hepatitis in children with tuberculosis: a case report and review of the literature
title_full Hepatitis in children with tuberculosis: a case report and review of the literature
title_fullStr Hepatitis in children with tuberculosis: a case report and review of the literature
title_full_unstemmed Hepatitis in children with tuberculosis: a case report and review of the literature
title_short Hepatitis in children with tuberculosis: a case report and review of the literature
title_sort hepatitis in children with tuberculosis: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298953/
https://www.ncbi.nlm.nih.gov/pubmed/32546255
http://dx.doi.org/10.1186/s12890-020-01215-6
work_keys_str_mv AT sanchezcodezmaria hepatitisinchildrenwithtuberculosisacasereportandreviewoftheliterature
AT huntwgarret hepatitisinchildrenwithtuberculosisacasereportandreviewoftheliterature
AT watsonjoshua hepatitisinchildrenwithtuberculosisacasereportandreviewoftheliterature
AT mejiasasuncion hepatitisinchildrenwithtuberculosisacasereportandreviewoftheliterature

Ejemplares similares