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Arsenic trioxide potentiates Gilteritinib-induced apoptosis in FLT3-ITD positive leukemic cells via IRE1a-JNK-mediated endoplasmic reticulum stress

BACKGROUND: Acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have a high relapse rate and poor prognosis. This study aims to explore the underlying mechanism of combining Gilteritinib with ATO at low concentration in the treatment of FLT3-I...

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Detalles Bibliográficos
Autores principales:	Hu, Xiaoli, Cai, Jiayi, Zhu, Jianyi, Lang, Wenjing, Zhong, Jihua, Zhong, Hua, Chen, Fangyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298957/ https://www.ncbi.nlm.nih.gov/pubmed/32565734 http://dx.doi.org/10.1186/s12935-020-01341-5

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