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Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design

BACKGROUND: The exact pathophysiology of atrial fibrillation (AF) remains incompletely understood and treatment of AF is associated with high recurrence rates. Persistence of AF is rooted in the presence of electropathology, defined as complex electrical conduction disorders caused by structural dam...

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Autores principales: Starreveld, Roeliene, Knops, Paul, Ramos, Kennedy S., Roos‐Serote, Maarten C., Bogers, Ad J.J.C., Brundel, Bianca J.J.M., de Groot, Natasja M.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298972/
https://www.ncbi.nlm.nih.gov/pubmed/32304106
http://dx.doi.org/10.1002/clc.23370
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author Starreveld, Roeliene
Knops, Paul
Ramos, Kennedy S.
Roos‐Serote, Maarten C.
Bogers, Ad J.J.C.
Brundel, Bianca J.J.M.
de Groot, Natasja M.S.
author_facet Starreveld, Roeliene
Knops, Paul
Ramos, Kennedy S.
Roos‐Serote, Maarten C.
Bogers, Ad J.J.C.
Brundel, Bianca J.J.M.
de Groot, Natasja M.S.
author_sort Starreveld, Roeliene
collection PubMed
description BACKGROUND: The exact pathophysiology of atrial fibrillation (AF) remains incompletely understood and treatment of AF is associated with high recurrence rates. Persistence of AF is rooted in the presence of electropathology, defined as complex electrical conduction disorders caused by structural damage of atrial tissue. The atrial fibrillation fingerprinting (AFFIP) study aims to characterize electropathology, enabling development of a novel diagnostic instrument to predict AF onset and early progression. HYPOTHESES: History of AF, development of post‐operative AF, age, gender, underlying heart disease, and other clinical characteristics impact the degree of electropathology. METHODS: This study is a prospective observational study with a planned duration of 48 months. Three study groups are defined: (1) patients with (longstanding) persistent AF, (2) patients with paroxysmal AF, and (3) patients without a history of AF, all undergoing open‐chest cardiac surgery. Intra‐operative high‐resolution epicardial mapping is performed to identify the patient‐specific electrical profile, whereas the patient‐specific biological profile is assessed by evaluating proteostasis markers in blood samples and atrial appendage tissue samples. Post‐operative continuous rhythm monitoring is performed for detection of early post‐operative AF. Late post‐operative AF (during 5‐year follow‐up) is documented by either electrocardiogram or 24‐hour Holter registration. RESULTS: The required sample size for this study is estimated at 447 patients. Up till now, 105 patients were included, of whom 36 have a history of AF. CONCLUSION: The AFFIP study will elucidate whether electrophysiological and structural characteristics represent a novel diagnostic tool, the AF fingerprint, to predict onset and early progression of AF in cardiac surgery patients.
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spelling pubmed-72989722020-06-18 Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design Starreveld, Roeliene Knops, Paul Ramos, Kennedy S. Roos‐Serote, Maarten C. Bogers, Ad J.J.C. Brundel, Bianca J.J.M. de Groot, Natasja M.S. Clin Cardiol Trial Designs BACKGROUND: The exact pathophysiology of atrial fibrillation (AF) remains incompletely understood and treatment of AF is associated with high recurrence rates. Persistence of AF is rooted in the presence of electropathology, defined as complex electrical conduction disorders caused by structural damage of atrial tissue. The atrial fibrillation fingerprinting (AFFIP) study aims to characterize electropathology, enabling development of a novel diagnostic instrument to predict AF onset and early progression. HYPOTHESES: History of AF, development of post‐operative AF, age, gender, underlying heart disease, and other clinical characteristics impact the degree of electropathology. METHODS: This study is a prospective observational study with a planned duration of 48 months. Three study groups are defined: (1) patients with (longstanding) persistent AF, (2) patients with paroxysmal AF, and (3) patients without a history of AF, all undergoing open‐chest cardiac surgery. Intra‐operative high‐resolution epicardial mapping is performed to identify the patient‐specific electrical profile, whereas the patient‐specific biological profile is assessed by evaluating proteostasis markers in blood samples and atrial appendage tissue samples. Post‐operative continuous rhythm monitoring is performed for detection of early post‐operative AF. Late post‐operative AF (during 5‐year follow‐up) is documented by either electrocardiogram or 24‐hour Holter registration. RESULTS: The required sample size for this study is estimated at 447 patients. Up till now, 105 patients were included, of whom 36 have a history of AF. CONCLUSION: The AFFIP study will elucidate whether electrophysiological and structural characteristics represent a novel diagnostic tool, the AF fingerprint, to predict onset and early progression of AF in cardiac surgery patients. Wiley Periodicals, Inc. 2020-04-18 /pmc/articles/PMC7298972/ /pubmed/32304106 http://dx.doi.org/10.1002/clc.23370 Text en © 2020 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Trial Designs
Starreveld, Roeliene
Knops, Paul
Ramos, Kennedy S.
Roos‐Serote, Maarten C.
Bogers, Ad J.J.C.
Brundel, Bianca J.J.M.
de Groot, Natasja M.S.
Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design
title Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design
title_full Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design
title_fullStr Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design
title_full_unstemmed Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design
title_short Atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (AFFIP): Rationale and design
title_sort atrial fibrillation fingerprinting; spotting bio‐electrical markers to early recognize atrial fibrillation by the use of a bottom‐up approach (affip): rationale and design
topic Trial Designs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298972/
https://www.ncbi.nlm.nih.gov/pubmed/32304106
http://dx.doi.org/10.1002/clc.23370
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