PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

Colorectal cancer (CRC) is a major cause of human death. Mortality is primarily due to metastatic organ colonization, with the liver being the main organ affected. We modeled metastatic CRC (mCRC) liver colonization using patient-derived primary and metastatic tumor xenografts (PDX). Such PDX modeli...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Norihiro, Weinberg, Ethan M, Nguyen, Alexander, Liberti, Maria V, Goodarzi, Hani, Janjigian, Yelena Y, Paty, Philip B, Saltz, Leonard B, Kingham, T Peter, Loo, Jia Min, de Stanchina, Elisa, Tavazoie, Sohail F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299340/
https://www.ncbi.nlm.nih.gov/pubmed/31841108
http://dx.doi.org/10.7554/eLife.52135

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