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Ankyrin-G mediates targeting of both Na(+) and K(ATP) channels to the rat cardiac intercalated disc

We investigated targeting mechanisms of Na(+) and K(ATP) channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density. Mutagenesis of the Kir6.2 ankyrin binding site disrupts this functional coupl...

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Detalles Bibliográficos
Autores principales:	Yang, Hua-Qian, Pérez-Hernández, Marta, Sanchez-Alonso, Jose, Shevchuk, Andriy, Gorelik, Julia, Rothenberg, Eli, Delmar, Mario, Coetzee, William A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Human Biology and Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299345/ https://www.ncbi.nlm.nih.gov/pubmed/31934859 http://dx.doi.org/10.7554/eLife.52373

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