Cargando…
Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms – A Cost-Benefit Analysis
BACKGROUND: Each year, influenza causes significant morbidity and death worldwide and produces significant economic losses at the expense of the healthcare system. OBJECTIVE: To assess the cost-benefit relationship of implementing a rapid point-of-care (POC) influenza test in emergency rooms (ERs) o...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Columbia Data Analytics, LLC
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299473/ https://www.ncbi.nlm.nih.gov/pubmed/32685592 http://dx.doi.org/10.36469/001c.11206 |
_version_ | 1783547395265527808 |
---|---|
author | Diel, Roland Nienhaus, Albert |
author_facet | Diel, Roland Nienhaus, Albert |
author_sort | Diel, Roland |
collection | PubMed |
description | BACKGROUND: Each year, influenza causes significant morbidity and death worldwide and produces significant economic losses at the expense of the healthcare system. OBJECTIVE: To assess the cost-benefit relationship of implementing a rapid point-of-care (POC) influenza test in emergency rooms (ERs) of German hospitals. METHODS: A deterministic decision-analytic model simulated the incremental costs of using the Sofia(®) Influenza A+B test compared to those of using clinical judgement alone to confirm or exclude influenza in adult ILI (influenza-like illness) patients in German ERs prior to hospitalization. Direct costs, with and without subsequent oseltamivir treatment, were evaluated from the hospital perspective as well as indirect costs incurred by nosocomial influenza transmission to hospital employees. RESULTS: In base-case analysis, taking the influenza prevalence of 25.9% in the season 2018/2019 and assuming a hospitalization rate among influenza suspects of 21.9%, rapid testing with the Sofia(®) followed by administering oseltamivir to patients testing positive reduced average costs of hospitalized ILI patients by €52.16 per tested patient. If oseltamivir was not offered, testing with the Sofia(®) reduced costs by €42.28 in favor of the hospital. In probabilistic sensitivity analysis, under all reasonable assumptions, implementing the Sofia(®) saved on average €119.89 as compared to applying the clinical-judgement-only strategy. The major part of the cost savings, €113.17 or 94.4%, was due to the POC test’s high specificity, which led to 91% reduction in needless bed-blocking on the first day of hospitalization. However, as the sensitivity of 75.3% was only slightly higher than that of conventional clinical judgement, improved classification of patients with true influenza and a correspondingly lower rate of illness in hospital employees could not be achieved. CONCLUSIONS: Using highly specific rapid POC influenza tests in ILI patients at German ER, despite their sub-optimal sensitivity, may significantly reduce hospital expenditures. |
format | Online Article Text |
id | pubmed-7299473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Columbia Data Analytics, LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-72994732020-07-16 Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms – A Cost-Benefit Analysis Diel, Roland Nienhaus, Albert J Health Econ Outcomes Res Infectious Diseases BACKGROUND: Each year, influenza causes significant morbidity and death worldwide and produces significant economic losses at the expense of the healthcare system. OBJECTIVE: To assess the cost-benefit relationship of implementing a rapid point-of-care (POC) influenza test in emergency rooms (ERs) of German hospitals. METHODS: A deterministic decision-analytic model simulated the incremental costs of using the Sofia(®) Influenza A+B test compared to those of using clinical judgement alone to confirm or exclude influenza in adult ILI (influenza-like illness) patients in German ERs prior to hospitalization. Direct costs, with and without subsequent oseltamivir treatment, were evaluated from the hospital perspective as well as indirect costs incurred by nosocomial influenza transmission to hospital employees. RESULTS: In base-case analysis, taking the influenza prevalence of 25.9% in the season 2018/2019 and assuming a hospitalization rate among influenza suspects of 21.9%, rapid testing with the Sofia(®) followed by administering oseltamivir to patients testing positive reduced average costs of hospitalized ILI patients by €52.16 per tested patient. If oseltamivir was not offered, testing with the Sofia(®) reduced costs by €42.28 in favor of the hospital. In probabilistic sensitivity analysis, under all reasonable assumptions, implementing the Sofia(®) saved on average €119.89 as compared to applying the clinical-judgement-only strategy. The major part of the cost savings, €113.17 or 94.4%, was due to the POC test’s high specificity, which led to 91% reduction in needless bed-blocking on the first day of hospitalization. However, as the sensitivity of 75.3% was only slightly higher than that of conventional clinical judgement, improved classification of patients with true influenza and a correspondingly lower rate of illness in hospital employees could not be achieved. CONCLUSIONS: Using highly specific rapid POC influenza tests in ILI patients at German ER, despite their sub-optimal sensitivity, may significantly reduce hospital expenditures. Columbia Data Analytics, LLC 2019-12-26 /pmc/articles/PMC7299473/ /pubmed/32685592 http://dx.doi.org/10.36469/001c.11206 Text en This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CCBY-4.0). View this license’s legal deed at http://creativecommons.org/licenses/by/4.0 and legal code at http://creativecommons.org/licenses/by/4.0/legalcode for more information. |
spellingShingle | Infectious Diseases Diel, Roland Nienhaus, Albert Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms – A Cost-Benefit Analysis |
title | Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms – A Cost-Benefit Analysis |
title_full | Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms – A Cost-Benefit Analysis |
title_fullStr | Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms – A Cost-Benefit Analysis |
title_full_unstemmed | Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms – A Cost-Benefit Analysis |
title_short | Rapid Point-of-Care Influenza Testing for Patients in German Emergency Rooms – A Cost-Benefit Analysis |
title_sort | rapid point-of-care influenza testing for patients in german emergency rooms – a cost-benefit analysis |
topic | Infectious Diseases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299473/ https://www.ncbi.nlm.nih.gov/pubmed/32685592 http://dx.doi.org/10.36469/001c.11206 |
work_keys_str_mv | AT dielroland rapidpointofcareinfluenzatestingforpatientsingermanemergencyroomsacostbenefitanalysis AT nienhausalbert rapidpointofcareinfluenzatestingforpatientsingermanemergencyroomsacostbenefitanalysis |