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Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity

Oxidatively-induced DNA damage, widely accepted as a key player in the onset of cancer, is predominantly repaired by base excision repair (BER). BER is initiated by DNA glycosylases, which locate and remove damaged bases from DNA. NTHL1 is a bifunctional DNA glycosylase in mammalian cells that predo...

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Detalles Bibliográficos
Autores principales:	Marsden, Carolyn G., Jaruga, Pawel, Coskun, Erdem, Maher, Robyn L., Pederson, David S., Dizdaroglu, Miral, Sweasy, Joann B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2020
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299534/ https://www.ncbi.nlm.nih.gov/pubmed/32595826 http://dx.doi.org/10.18632/oncotarget.27548

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