Cargando…
Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries
PURPOSE: Current acceptance of the watch-and-wait (W&W) approach by surgeons in Asia-Pacific countries is unknown. An international survey was performed to determine status of the W&W approach on behalf of the Asia-Pacific Federation of Coloproctology (APFCP). METHODS: Surgeons in the APFCP...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Coloproctology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299564/ https://www.ncbi.nlm.nih.gov/pubmed/32054250 http://dx.doi.org/10.3393/ac.2020.01.19 |
_version_ | 1783547412275527680 |
---|---|
author | Huh, Jung Wook Maeda, Kotaro Liu, Zheng Wang, Xishan Roslani, April Camilla Lee, Woo Yong |
author_facet | Huh, Jung Wook Maeda, Kotaro Liu, Zheng Wang, Xishan Roslani, April Camilla Lee, Woo Yong |
author_sort | Huh, Jung Wook |
collection | PubMed |
description | PURPOSE: Current acceptance of the watch-and-wait (W&W) approach by surgeons in Asia-Pacific countries is unknown. An international survey was performed to determine status of the W&W approach on behalf of the Asia-Pacific Federation of Coloproctology (APFCP). METHODS: Surgeons in the APFCP completed an Institutional Review Board-approved anonymous e-survey and/or printed letters (for China) containing 19 questions regarding nonsurgical close observation in patients who achieved clinical complete response (cCR) to neoadjuvant chemoradiotherapy (nCRT). RESULTS: Of the 417 responses, 80.8% (n = 337) supported the W&W approach and 65.5% (n = 273) treated patients who achieved cCR after nCRT. Importantly, 78% of participants (n = 326) preferred a selective W&W approach in patients with old age and medical comorbidities who achieved cCR. In regard to restaging methods after nCRT, the majority of respondents based their decision to use W&W on a combination of magnetic resonance imaging results (94.5%, n = 394) with other test results. For interval between nCRT completion and tumor response assessment, most participants used 8 weeks (n = 154, 36.9%), followed by 6 weeks (n = 127, 30.5%) and 4 weeks (n = 102, 24.5%). In response to the question of how often responders followed-up after W&W, the predominant period was every 3 months (209 participants, 50.1%) followed by every 2 months (75 participants, 18.0%). If local regrowth was found during follow-up, most participants (79.9%, n = 333) recommended radical surgery as an initial management. CONCLUSION: The W&W approach is supported by 80% of Asia-Pacific surgeons and is practiced at 65%, although heterogeneous hospital or society protocols are also observed. These results inform oncologists of future clinical study participation. |
format | Online Article Text |
id | pubmed-7299564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society of Coloproctology |
record_format | MEDLINE/PubMed |
spelling | pubmed-72995642020-06-19 Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries Huh, Jung Wook Maeda, Kotaro Liu, Zheng Wang, Xishan Roslani, April Camilla Lee, Woo Yong Ann Coloproctol Current Practice in Asia-Pacific Region PURPOSE: Current acceptance of the watch-and-wait (W&W) approach by surgeons in Asia-Pacific countries is unknown. An international survey was performed to determine status of the W&W approach on behalf of the Asia-Pacific Federation of Coloproctology (APFCP). METHODS: Surgeons in the APFCP completed an Institutional Review Board-approved anonymous e-survey and/or printed letters (for China) containing 19 questions regarding nonsurgical close observation in patients who achieved clinical complete response (cCR) to neoadjuvant chemoradiotherapy (nCRT). RESULTS: Of the 417 responses, 80.8% (n = 337) supported the W&W approach and 65.5% (n = 273) treated patients who achieved cCR after nCRT. Importantly, 78% of participants (n = 326) preferred a selective W&W approach in patients with old age and medical comorbidities who achieved cCR. In regard to restaging methods after nCRT, the majority of respondents based their decision to use W&W on a combination of magnetic resonance imaging results (94.5%, n = 394) with other test results. For interval between nCRT completion and tumor response assessment, most participants used 8 weeks (n = 154, 36.9%), followed by 6 weeks (n = 127, 30.5%) and 4 weeks (n = 102, 24.5%). In response to the question of how often responders followed-up after W&W, the predominant period was every 3 months (209 participants, 50.1%) followed by every 2 months (75 participants, 18.0%). If local regrowth was found during follow-up, most participants (79.9%, n = 333) recommended radical surgery as an initial management. CONCLUSION: The W&W approach is supported by 80% of Asia-Pacific surgeons and is practiced at 65%, although heterogeneous hospital or society protocols are also observed. These results inform oncologists of future clinical study participation. Korean Society of Coloproctology 2020-04 2020-01-31 /pmc/articles/PMC7299564/ /pubmed/32054250 http://dx.doi.org/10.3393/ac.2020.01.19 Text en Copyright © 2020 The Korean Society of Coloproctology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Current Practice in Asia-Pacific Region Huh, Jung Wook Maeda, Kotaro Liu, Zheng Wang, Xishan Roslani, April Camilla Lee, Woo Yong Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries |
title | Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries |
title_full | Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries |
title_fullStr | Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries |
title_full_unstemmed | Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries |
title_short | Current Status of “Watch-and-Wait” Rectal Cancer Treatment in Asia-Pacific Countries |
title_sort | current status of “watch-and-wait” rectal cancer treatment in asia-pacific countries |
topic | Current Practice in Asia-Pacific Region |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299564/ https://www.ncbi.nlm.nih.gov/pubmed/32054250 http://dx.doi.org/10.3393/ac.2020.01.19 |
work_keys_str_mv | AT huhjungwook currentstatusofwatchandwaitrectalcancertreatmentinasiapacificcountries AT maedakotaro currentstatusofwatchandwaitrectalcancertreatmentinasiapacificcountries AT liuzheng currentstatusofwatchandwaitrectalcancertreatmentinasiapacificcountries AT wangxishan currentstatusofwatchandwaitrectalcancertreatmentinasiapacificcountries AT roslaniaprilcamilla currentstatusofwatchandwaitrectalcancertreatmentinasiapacificcountries AT leewooyong currentstatusofwatchandwaitrectalcancertreatmentinasiapacificcountries |