TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis

The TET2 DNA hydroxymethyltransferase is frequently disrupted by somatic mutations in diffuse large B cell lymphomas (DLBCLs), a tumor that originates from germinal center (GC) B cells. Here, we show that TET2 deficiency leads to DNA hypermethylation of regulatory elements in GC B cells, associated...

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Detalles Bibliográficos
Autores principales: Rosikiewicz, Wojciech, Chen, Xiaowen, Dominguez, Pilar M., Ghamlouch, Hussein, Aoufouchi, Said, Bernard, Olivier A., Melnick, Ari, Li, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299612/
https://www.ncbi.nlm.nih.gov/pubmed/32596441
http://dx.doi.org/10.1126/sciadv.aay5872

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