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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells
Transcriptional bursting is the stochastic activation and inactivation of promoters, contributing to cell-to-cell heterogeneity in gene expression. However, the mechanism underlying the regulation of transcriptional bursting kinetics (burst size and frequency) in mammalian cells remains elusive. In...
Autores principales: | Ochiai, Hiroshi, Hayashi, Tetsutaro, Umeda, Mana, Yoshimura, Mika, Harada, Akihito, Shimizu, Yukiko, Nakano, Kenta, Saitoh, Noriko, Liu, Zhe, Yamamoto, Takashi, Okamura, Tadashi, Ohkawa, Yasuyuki, Kimura, Hiroshi, Nikaido, Itoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299619/ https://www.ncbi.nlm.nih.gov/pubmed/32596448 http://dx.doi.org/10.1126/sciadv.aaz6699 |
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