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Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope
Developmental shifts in stage-specific gene expression can provide a ready mechanism of phenotypic change by altering the rate or timing of ontogenetic events. We found that the high-altitude Tibetan antelope (Panthelops hodgsonii) has evolved an adaptive increase in blood-O(2) affinity by truncatin...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299627/ https://www.ncbi.nlm.nih.gov/pubmed/32596473 http://dx.doi.org/10.1126/sciadv.abb5447 |
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author | Signore, Anthony V. Storz, Jay F. |
author_facet | Signore, Anthony V. Storz, Jay F. |
author_sort | Signore, Anthony V. |
collection | PubMed |
description | Developmental shifts in stage-specific gene expression can provide a ready mechanism of phenotypic change by altering the rate or timing of ontogenetic events. We found that the high-altitude Tibetan antelope (Panthelops hodgsonii) has evolved an adaptive increase in blood-O(2) affinity by truncating the ancestral ontogeny of globin gene expression such that a high-affinity juvenile hemoglobin isoform (isoHb) completely supplants the lower-affinity isoHb that is expressed in the adult red blood cells of other bovids. This juvenilization of blood properties represents a canalization of an acclimatization response to hypoxia that has been well documented in adult goats and sheep. We also found the genomic mechanism underlying this regulatory isoHb switch, revealing how a reversible acclimatization response became genetically assimilated as an irreversible adaptation to chronic hypoxia. |
format | Online Article Text |
id | pubmed-7299627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-72996272020-06-25 Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope Signore, Anthony V. Storz, Jay F. Sci Adv Research Articles Developmental shifts in stage-specific gene expression can provide a ready mechanism of phenotypic change by altering the rate or timing of ontogenetic events. We found that the high-altitude Tibetan antelope (Panthelops hodgsonii) has evolved an adaptive increase in blood-O(2) affinity by truncating the ancestral ontogeny of globin gene expression such that a high-affinity juvenile hemoglobin isoform (isoHb) completely supplants the lower-affinity isoHb that is expressed in the adult red blood cells of other bovids. This juvenilization of blood properties represents a canalization of an acclimatization response to hypoxia that has been well documented in adult goats and sheep. We also found the genomic mechanism underlying this regulatory isoHb switch, revealing how a reversible acclimatization response became genetically assimilated as an irreversible adaptation to chronic hypoxia. American Association for the Advancement of Science 2020-06-17 /pmc/articles/PMC7299627/ /pubmed/32596473 http://dx.doi.org/10.1126/sciadv.abb5447 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Signore, Anthony V. Storz, Jay F. Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope |
title | Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope |
title_full | Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope |
title_fullStr | Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope |
title_full_unstemmed | Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope |
title_short | Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope |
title_sort | biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of tibetan antelope |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299627/ https://www.ncbi.nlm.nih.gov/pubmed/32596473 http://dx.doi.org/10.1126/sciadv.abb5447 |
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