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The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience

Background Breast cancer is the most common cancer affecting women in Germany. Despite breast-conserving therapy (BCT) being carried out in almost 70% of cases, a high number of women still require complete mastectomy. Prophylactic mastectomy is also indicated for women with a BRCA 1/2 gene mutation...

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Autores principales: Munder, Beatrix, Andree, Christoph, Witzel, Christian, Fertsch, Sonia, Stambera, Peter, Schulz, Tino, Fleischer, Olaf, Hagouan, Mazen, Grüter, Lukas, Aufmesser, Birgit, Staemmler, Katinka, Kornetka, Julia, Aldeeri, Mohammed, Seidenstücker, Katrin, Abu-Ghazaleh, Alina, Wolter, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299686/
https://www.ncbi.nlm.nih.gov/pubmed/32565553
http://dx.doi.org/10.1055/a-1116-2102
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author Munder, Beatrix
Andree, Christoph
Witzel, Christian
Fertsch, Sonia
Stambera, Peter
Schulz, Tino
Fleischer, Olaf
Hagouan, Mazen
Grüter, Lukas
Aufmesser, Birgit
Staemmler, Katinka
Kornetka, Julia
Aldeeri, Mohammed
Seidenstücker, Katrin
Abu-Ghazaleh, Alina
Wolter, Andreas
author_facet Munder, Beatrix
Andree, Christoph
Witzel, Christian
Fertsch, Sonia
Stambera, Peter
Schulz, Tino
Fleischer, Olaf
Hagouan, Mazen
Grüter, Lukas
Aufmesser, Birgit
Staemmler, Katinka
Kornetka, Julia
Aldeeri, Mohammed
Seidenstücker, Katrin
Abu-Ghazaleh, Alina
Wolter, Andreas
author_sort Munder, Beatrix
collection PubMed
description Background Breast cancer is the most common cancer affecting women in Germany. Despite breast-conserving therapy (BCT) being carried out in almost 70% of cases, a high number of women still require complete mastectomy. Prophylactic mastectomy is also indicated for women with a BRCA 1/2 gene mutation. In addition to implant-based heterologous breast reconstruction, autologous breast reconstruction using a DIEP flap has been found to be beneficial, particularly for patients who had prior radiotherapy. This study aims to show that DIEP flap reconstruction surgery is the method of choice for autologous breast reconstruction with a low rate of complications. Patients and Methods Autologous breast reconstruction using a DIEP flap was performed in 1124 patients between July 2004 and December 2014. Retrospective study criteria included potential risk factors such as age, BMI, smoking, chemotherapy and/or radiotherapy, and comorbidities as well as outcome parameters such as postoperative complications. Outcomes were evaluated with a mean follow-up of 24 months. Results A total of 1124 patients underwent 1274 free DIEP flap breast reconstructions, of which 150 were bilateral reconstructions. The primary indication was previous mastectomy in 785 cases, followed by prior implant-based reconstruction in 265 cases. The total flap loss rate was 0.6%. Postoperative surgical revision for abdominal wall hernia was required in 0.2% of cases. The group with a higher BMI and the group of smokers had significantly higher complication rates. Elderly patients (> 65 years), patients who had undergone chemo-/radiotherapy and patients with diabetes did not have higher complication rates. Conclusion DIEP flap surgery is an excellent option for autologous breast reconstruction, with a low rate of donor site morbidity and low complication rates. DIEP flap surgery carried out in a specialised interdisciplinary breast centre in a standardised clinical setting after prior careful patient selection to take account of risk factors such as high BMI and smoking is a reliable method with a low complication rate and satisfactory long-term reconstruction results.
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spelling pubmed-72996862020-06-19 The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience Munder, Beatrix Andree, Christoph Witzel, Christian Fertsch, Sonia Stambera, Peter Schulz, Tino Fleischer, Olaf Hagouan, Mazen Grüter, Lukas Aufmesser, Birgit Staemmler, Katinka Kornetka, Julia Aldeeri, Mohammed Seidenstücker, Katrin Abu-Ghazaleh, Alina Wolter, Andreas Geburtshilfe Frauenheilkd Background Breast cancer is the most common cancer affecting women in Germany. Despite breast-conserving therapy (BCT) being carried out in almost 70% of cases, a high number of women still require complete mastectomy. Prophylactic mastectomy is also indicated for women with a BRCA 1/2 gene mutation. In addition to implant-based heterologous breast reconstruction, autologous breast reconstruction using a DIEP flap has been found to be beneficial, particularly for patients who had prior radiotherapy. This study aims to show that DIEP flap reconstruction surgery is the method of choice for autologous breast reconstruction with a low rate of complications. Patients and Methods Autologous breast reconstruction using a DIEP flap was performed in 1124 patients between July 2004 and December 2014. Retrospective study criteria included potential risk factors such as age, BMI, smoking, chemotherapy and/or radiotherapy, and comorbidities as well as outcome parameters such as postoperative complications. Outcomes were evaluated with a mean follow-up of 24 months. Results A total of 1124 patients underwent 1274 free DIEP flap breast reconstructions, of which 150 were bilateral reconstructions. The primary indication was previous mastectomy in 785 cases, followed by prior implant-based reconstruction in 265 cases. The total flap loss rate was 0.6%. Postoperative surgical revision for abdominal wall hernia was required in 0.2% of cases. The group with a higher BMI and the group of smokers had significantly higher complication rates. Elderly patients (> 65 years), patients who had undergone chemo-/radiotherapy and patients with diabetes did not have higher complication rates. Conclusion DIEP flap surgery is an excellent option for autologous breast reconstruction, with a low rate of donor site morbidity and low complication rates. DIEP flap surgery carried out in a specialised interdisciplinary breast centre in a standardised clinical setting after prior careful patient selection to take account of risk factors such as high BMI and smoking is a reliable method with a low complication rate and satisfactory long-term reconstruction results. Georg Thieme Verlag KG 2020-06 2020-04-16 /pmc/articles/PMC7299686/ /pubmed/32565553 http://dx.doi.org/10.1055/a-1116-2102 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Munder, Beatrix
Andree, Christoph
Witzel, Christian
Fertsch, Sonia
Stambera, Peter
Schulz, Tino
Fleischer, Olaf
Hagouan, Mazen
Grüter, Lukas
Aufmesser, Birgit
Staemmler, Katinka
Kornetka, Julia
Aldeeri, Mohammed
Seidenstücker, Katrin
Abu-Ghazaleh, Alina
Wolter, Andreas
The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience
title The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience
title_full The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience
title_fullStr The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience
title_full_unstemmed The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience
title_short The DIEP Flap as Well-established Method of Choice for Autologous Breast Reconstruction with a Low Complication Rate – Retrospective Single-centre 10-Year Experience
title_sort diep flap as well-established method of choice for autologous breast reconstruction with a low complication rate – retrospective single-centre 10-year experience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299686/
https://www.ncbi.nlm.nih.gov/pubmed/32565553
http://dx.doi.org/10.1055/a-1116-2102
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