Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?

• COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks. • Some are being required to continue in isolation until they have negative results. • SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious. • Quantitative RT-PCRs and immunoassays are bett...

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Detalles Bibliográficos
Autores principales: Krupp, Karl, Madhivanan, Purnima, Perez-Velez, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299851/
https://www.ncbi.nlm.nih.gov/pubmed/32562790
http://dx.doi.org/10.1016/j.jinf.2020.06.030
Descripción
Sumario:• COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks. • Some are being required to continue in isolation until they have negative results. • SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious. • Quantitative RT-PCRs and immunoassays are better markers of infectivity period. • Social isolation can have economic, physical, psychological, and social effects.

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