Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?

• COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks. • Some are being required to continue in isolation until they have negative results. • SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious. • Quantitative RT-PCRs and immunoassays are bett...

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Autores principales: Krupp, Karl, Madhivanan, Purnima, Perez-Velez, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299851/
https://www.ncbi.nlm.nih.gov/pubmed/32562790
http://dx.doi.org/10.1016/j.jinf.2020.06.030
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author Krupp, Karl
Madhivanan, Purnima
Perez-Velez, Carlos M.
author_facet Krupp, Karl
Madhivanan, Purnima
Perez-Velez, Carlos M.
author_sort Krupp, Karl
collection PubMed
description • COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks. • Some are being required to continue in isolation until they have negative results. • SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious. • Quantitative RT-PCRs and immunoassays are better markers of infectivity period. • Social isolation can have economic, physical, psychological, and social effects.
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spelling pubmed-72998512020-06-18 Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients? Krupp, Karl Madhivanan, Purnima Perez-Velez, Carlos M. J Infect Article • COVID-19 patients may have persistently positive RT-PCRs for as many as 9 weeks. • Some are being required to continue in isolation until they have negative results. • SARS-CoV-2 qualitative RT-PCR does not distinguish infectious from noninfectious. • Quantitative RT-PCRs and immunoassays are better markers of infectivity period. • Social isolation can have economic, physical, psychological, and social effects. The British Infection Association. Published by Elsevier Ltd. 2020-06-18 /pmc/articles/PMC7299851/ /pubmed/32562790 http://dx.doi.org/10.1016/j.jinf.2020.06.030 Text en © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Krupp, Karl
Madhivanan, Purnima
Perez-Velez, Carlos M.
Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?
title Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?
title_full Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?
title_fullStr Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?
title_full_unstemmed Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?
title_short Should qualitative RT-PCR be used to determine release from isolation of COVID-19 patients?
title_sort should qualitative rt-pcr be used to determine release from isolation of covid-19 patients?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299851/
https://www.ncbi.nlm.nih.gov/pubmed/32562790
http://dx.doi.org/10.1016/j.jinf.2020.06.030
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