A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19

SARS-CoV-2, a member of the coronavirus family, is responsible for the current COVID-19 worldwide pandemic. We previously demonstrated that five nucleotide analogues inhibit the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), including the active triphosphate forms of Sofosbuvir, Alovudine, Zidovudi...

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Detalles Bibliográficos
Autores principales: Jockusch, Steffen, Tao, Chuanjuan, Li, Xiaoxu, Anderson, Thomas K., Chien, Minchen, Kumar, Shiv, Russo, James J., Kirchdoerfer, Robert N., Ju, Jingyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299870/
https://www.ncbi.nlm.nih.gov/pubmed/32562705
http://dx.doi.org/10.1016/j.antiviral.2020.104857

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