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Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age

Several studies in patients with chronic kidney disease or normal renal function have shown that high levels of tissue non-specific alkaline phosphatase (ALP) are associated with an increased risk of all cause and cardiovascular (CV) mortality. Considering the independent prognostic role of renal fu...

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Autores principales: Sciacqua, Angela, Tripepi, Giovanni, Perticone, Maria, Cassano, Velia, Fiorentino, Teresa V., Pititto, Gerardo N., Maio, Raffaele, Miceli, Sofia, Andreozzi, Francesco, Sesti, Giorgio, Perticone, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299930/
https://www.ncbi.nlm.nih.gov/pubmed/32555235
http://dx.doi.org/10.1038/s41598-020-66911-z
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author Sciacqua, Angela
Tripepi, Giovanni
Perticone, Maria
Cassano, Velia
Fiorentino, Teresa V.
Pititto, Gerardo N.
Maio, Raffaele
Miceli, Sofia
Andreozzi, Francesco
Sesti, Giorgio
Perticone, Francesco
author_facet Sciacqua, Angela
Tripepi, Giovanni
Perticone, Maria
Cassano, Velia
Fiorentino, Teresa V.
Pititto, Gerardo N.
Maio, Raffaele
Miceli, Sofia
Andreozzi, Francesco
Sesti, Giorgio
Perticone, Francesco
author_sort Sciacqua, Angela
collection PubMed
description Several studies in patients with chronic kidney disease or normal renal function have shown that high levels of tissue non-specific alkaline phosphatase (ALP) are associated with an increased risk of all cause and cardiovascular (CV) mortality. Considering the independent prognostic role of renal function, we investigated the possible association between ALP levels and estimated glomerular filtration rate (e-GFR) in a large cohort of hypertensive subjects. We enrolled 2157 never-treated uncomplicated hypertensive patients with ALP levels within normal range. In the whole population, e-GFR was strongly related to ALP (r = −0.43, P < 0.0001) with similar magnitude in females and in males, resulting ALP the second independent predictor of renal function. In a multiple linear regression model, both on crude (P < 0.001) and adjusted (P = 0.01) analyses age significantly modified the effect of a fixed increase in ALP (20 UI/L) on renal function so that the reduction in e-GFR associated to a 20 UI/L increase in ALP was of lower magnitude in younger patients and progressively of higher extent from 20 years of age onwards. In conclusion, present data indicate a significant relationship between ALP levels and e-GFR in uncomplicated hypertensive patients that is modulated by age and that persisted after adjusting for several confounders.
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spelling pubmed-72999302020-06-18 Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age Sciacqua, Angela Tripepi, Giovanni Perticone, Maria Cassano, Velia Fiorentino, Teresa V. Pititto, Gerardo N. Maio, Raffaele Miceli, Sofia Andreozzi, Francesco Sesti, Giorgio Perticone, Francesco Sci Rep Article Several studies in patients with chronic kidney disease or normal renal function have shown that high levels of tissue non-specific alkaline phosphatase (ALP) are associated with an increased risk of all cause and cardiovascular (CV) mortality. Considering the independent prognostic role of renal function, we investigated the possible association between ALP levels and estimated glomerular filtration rate (e-GFR) in a large cohort of hypertensive subjects. We enrolled 2157 never-treated uncomplicated hypertensive patients with ALP levels within normal range. In the whole population, e-GFR was strongly related to ALP (r = −0.43, P < 0.0001) with similar magnitude in females and in males, resulting ALP the second independent predictor of renal function. In a multiple linear regression model, both on crude (P < 0.001) and adjusted (P = 0.01) analyses age significantly modified the effect of a fixed increase in ALP (20 UI/L) on renal function so that the reduction in e-GFR associated to a 20 UI/L increase in ALP was of lower magnitude in younger patients and progressively of higher extent from 20 years of age onwards. In conclusion, present data indicate a significant relationship between ALP levels and e-GFR in uncomplicated hypertensive patients that is modulated by age and that persisted after adjusting for several confounders. Nature Publishing Group UK 2020-06-17 /pmc/articles/PMC7299930/ /pubmed/32555235 http://dx.doi.org/10.1038/s41598-020-66911-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sciacqua, Angela
Tripepi, Giovanni
Perticone, Maria
Cassano, Velia
Fiorentino, Teresa V.
Pititto, Gerardo N.
Maio, Raffaele
Miceli, Sofia
Andreozzi, Francesco
Sesti, Giorgio
Perticone, Francesco
Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age
title Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age
title_full Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age
title_fullStr Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age
title_full_unstemmed Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age
title_short Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age
title_sort alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299930/
https://www.ncbi.nlm.nih.gov/pubmed/32555235
http://dx.doi.org/10.1038/s41598-020-66911-z
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