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CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

Human arylamine N-acetyltransferase 1 (NAT1), present in all tissues, is classically described as a phase-II xenobiotic metabolizing enzyme but can also catalyze the hydrolysis of acetyl-Coenzyme A (acetyl-CoA) in the absence of an arylamine substrate using folate as a cofactor. NAT1 activity varies...

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Detalles Bibliográficos
Autores principales:	Carlisle, Samantha M., Trainor, Patrick J., Hong, Kyung U., Doll, Mark A., Hein, David W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299936/ https://www.ncbi.nlm.nih.gov/pubmed/32555504 http://dx.doi.org/10.1038/s41598-020-66863-4

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