PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome

The ubiquitin ligase, Ube3a, plays important roles in brain development and functions, since its deficiency results in Angelman Syndrome (AS) while its over-expression increases the risk for autism. We previously showed that the lack of Ube3a-mediated ubiquitination of the Ca(2+)-activated small con...

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Detalles Bibliográficos
Autores principales: Sun, Jiandong, Liu, Yan, Zhu, Guoqi, Cato, Caleb, Hao, Xiaoning, Qian, Li, Lin, Weiju, Adhikari, Rachana, Luo, Yun, Baudry, Michel, Bi, Xiaoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299966/
https://www.ncbi.nlm.nih.gov/pubmed/32555345
http://dx.doi.org/10.1038/s41598-020-66790-4

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