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Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA

Unlimited access to calorie-dense, palatable food is a hallmark of Western societies and substantially contributes to the worldwide rise of metabolic disorders. In addition to promoting overconsumption, palatable diets dampen daily intake patterns, further augmenting metabolic disruption. We develop...

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Autores principales: Koch, C. E., Begemann, K., Kiehn, J. T., Griewahn, L., Mauer, J., M. E. Hess, Moser, A., Schmid, S. M., Brüning, J. C., Oster, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299974/
https://www.ncbi.nlm.nih.gov/pubmed/32555162
http://dx.doi.org/10.1038/s41467-020-16882-6
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author Koch, C. E.
Begemann, K.
Kiehn, J. T.
Griewahn, L.
Mauer, J.
M. E. Hess
Moser, A.
Schmid, S. M.
Brüning, J. C.
Oster, H.
author_facet Koch, C. E.
Begemann, K.
Kiehn, J. T.
Griewahn, L.
Mauer, J.
M. E. Hess
Moser, A.
Schmid, S. M.
Brüning, J. C.
Oster, H.
author_sort Koch, C. E.
collection PubMed
description Unlimited access to calorie-dense, palatable food is a hallmark of Western societies and substantially contributes to the worldwide rise of metabolic disorders. In addition to promoting overconsumption, palatable diets dampen daily intake patterns, further augmenting metabolic disruption. We developed a paradigm to reveal differential timing in the regulation of food intake behavior in mice. While homeostatic intake peaks in the active phase, conditioned place preference and choice experiments show an increased sensitivity to overeating on palatable food during the rest phase. This hedonic appetite rhythm is driven by endogenous circadian clocks in dopaminergic neurons of the ventral tegmental area (VTA). Mice with disrupted clock function in the VTA lose their hedonic overconsumption rhythms without affecting homeostatic intake. These findings assign a functional role of VTA clocks in modulating palatable feeding behaviors and identify a potential therapeutic route to counteract hyperphagy in an obesogenic environment.
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spelling pubmed-72999742020-06-22 Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA Koch, C. E. Begemann, K. Kiehn, J. T. Griewahn, L. Mauer, J. M. E. Hess Moser, A. Schmid, S. M. Brüning, J. C. Oster, H. Nat Commun Article Unlimited access to calorie-dense, palatable food is a hallmark of Western societies and substantially contributes to the worldwide rise of metabolic disorders. In addition to promoting overconsumption, palatable diets dampen daily intake patterns, further augmenting metabolic disruption. We developed a paradigm to reveal differential timing in the regulation of food intake behavior in mice. While homeostatic intake peaks in the active phase, conditioned place preference and choice experiments show an increased sensitivity to overeating on palatable food during the rest phase. This hedonic appetite rhythm is driven by endogenous circadian clocks in dopaminergic neurons of the ventral tegmental area (VTA). Mice with disrupted clock function in the VTA lose their hedonic overconsumption rhythms without affecting homeostatic intake. These findings assign a functional role of VTA clocks in modulating palatable feeding behaviors and identify a potential therapeutic route to counteract hyperphagy in an obesogenic environment. Nature Publishing Group UK 2020-06-17 /pmc/articles/PMC7299974/ /pubmed/32555162 http://dx.doi.org/10.1038/s41467-020-16882-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Koch, C. E.
Begemann, K.
Kiehn, J. T.
Griewahn, L.
Mauer, J.
M. E. Hess
Moser, A.
Schmid, S. M.
Brüning, J. C.
Oster, H.
Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA
title Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA
title_full Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA
title_fullStr Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA
title_full_unstemmed Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA
title_short Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA
title_sort circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the vta
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299974/
https://www.ncbi.nlm.nih.gov/pubmed/32555162
http://dx.doi.org/10.1038/s41467-020-16882-6
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