p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs

Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division and responsible for tumor recurrence. Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed and contributes to p53 degradation in TICs. Here we identify TBC1D15-mediated oncogen...

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Detalles Bibliográficos
Autores principales: Choi, Hye Yeon, Siddique, Hifzur R., Zheng, Mengmei, Kou, Yi, Yeh, Da-Wei, Machida, Tatsuya, Chen, Chia-Lin, Uthaya Kumar, Dinesh Babu, Punj, Vasu, Winer, Peleg, Pita, Alejandro, Sher, Linda, Tahara, Stanley M., Ray, Ratna B., Liang, Chengyu, Chen, Lin, Tsukamoto, Hidekazu, Machida, Keigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299990/
https://www.ncbi.nlm.nih.gov/pubmed/32555153
http://dx.doi.org/10.1038/s41467-020-16616-8

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