Cargando…

Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation

Molecular chaperones assist proteins in achieving a functional structure and prevent them from misfolding into aggregates, including disease-associated deposits. The BRICHOS domain from familial dementia associated protein Bri2 (or ITM2B) probably chaperones its specific proprotein region with high...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poska, Helen, Leppert, Axel, Tigro, Helene, Zhong, Xueying, Kaldmäe, Margit, Nilsson, Harriet E, Hebert, Hans, Chen, Gefei, Johansson, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299998/ https://www.ncbi.nlm.nih.gov/pubmed/32555390 http://dx.doi.org/10.1038/s41598-020-66718-y

Ejemplares similares

Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation
por: Chen, Gefei, et al.
Publicado: (2023)

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
por: Chen, Gefei, et al.
Publicado: (2017)

The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ(42) and Alzheimer Amyloid Plaques
por: Dolfe, Lisa, et al.
Publicado: (2018)

A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain
por: Leppert, Axel, et al.
Publicado: (2023)

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro
por: Chen, Gefei, et al.
Publicado: (2020)

Functionalization of amyloid fibrils via the Bri2 BRICHOS domain
por: Biverstål, Henrik, et al.
Publicado: (2020)

Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro
por: Oliveira, Daniel V., et al.
Publicado: (2022)

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue
por: Chen, Gefei, et al.
Publicado: (2022)

Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture
por: Schmuck, Benjamin, et al.
Publicado: (2021)

Amyloid Fibril Formation of Arctic Amyloid-β 1–42 Peptide is Efficiently Inhibited by the BRICHOS Domain
por: Zhong, Xueying, et al.
Publicado: (2022)

BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells
por: Oskarsson, Marie E., et al.
Publicado: (2018)

Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone
por: Kumar, Rakesh, et al.
Publicado: (2023)

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster
por: Hermansson, Erik, et al.
Publicado: (2014)

The molecular chaperone Brichos breaks the catalytic cycle that generates toxic Aβ oligomers
por: Cohen, Samuel I. A., et al.
Publicado: (2015)

A “grappling hook” interaction connects self-assembly and chaperone activity of Nucleophosmin 1
por: Saluri, Mihkel, et al.
Publicado: (2023)

ATP‐independent molecular chaperone activity generated under reducing conditions
por: Leppert, Axel, et al.
Publicado: (2022)

BRICHOS - a superfamily of multidomain proteins with diverse functions
por: Hedlund, Joel, et al.
Publicado: (2009)

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation
por: Ruggeri, F. S., et al.
Publicado: (2015)

Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain
por: Leppert, Axel, et al.
Publicado: (2021)

The molecular chaperone β-casein prevents amorphous and fibrillar aggregation of α-lactalbumin by stabilisation of dynamic disorder
por: Sanders, Henry M., et al.
Publicado: (2020)

OAF: a new member of the BRICHOS family
por: Sanchez-Pulido, Luis, et al.
Publicado: (2022)

β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
por: Banerjee, Siddhartha, et al.
Publicado: (2023)

Is there a sodium effect in fibrillar amyloid-β oligomers?
por: Horn, Anselm HC, et al.
Publicado: (2014)

Fibrillar Amyloid Plaque Formation Precedes Microglial Activation
por: Jung, Christian K. E., et al.
Publicado: (2015)

Conservation of the Amyloid Interactome Across Diverse Fibrillar Structures
por: Juhl, Dennis Wilkens, et al.
Publicado: (2019)

Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System
por: Buxbaum, Joel N., et al.
Publicado: (2017)

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates
por: Morimoto, Daichi, et al.
Publicado: (2015)

Structural polymorphisms in fibrillar aggregates associated with exfoliation syndrome
por: Ghaffari Sharaf, Mehdi, et al.
Publicado: (2020)

Amyloid inhibition by molecular chaperones in vitro can be translated to Alzheimer's pathology in vivo
por: Abelein, Axel, et al.
Publicado: (2023)

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
por: Picone, Pasquale, et al.
Publicado: (2016)

Small molecule-mediated co-assembly of amyloid-β oligomers reduces neurotoxicity through promoting non-fibrillar aggregation
por: Liu, Hao, et al.
Publicado: (2020)

Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates
por: Lazarev, Vladimir F., et al.
Publicado: (2017)

Stability of single and double layer fibrillar amyloid-β oligomers
por: Kahler, Anna, et al.
Publicado: (2013)

Cerebral Amyloid Angiopathy and Parenchymal Amyloid Deposition in Transgenic Mice Expressing the Danish Mutant Form of Human BRI(2)
por: Vidal, Ruben, et al.
Publicado: (2008)

The best of SBP-BRiMS
por: Carley, Kathleen M.
Publicado: (2020)

Characterization of cp3 reveals a new bri1 allele, bri1-120, and the importance of the LRR domain of BRI1 mediating BR signaling
por: Shang, Yun, et al.
Publicado: (2011)

High intracellular stability of the spidroin N‐terminal domain in spite of abundant amyloidogenic segments revealed by in‐cell hydrogen/deuterium exchange mass spectrometry
por: Kaldmäe, Margit, et al.
Publicado: (2019)

A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease
por: Nordberg, Agneta, et al.
Publicado: (2012)

Homeless people as target population in the scientific investigation
por: Kaldmäe, Margit
Publicado: (2012)

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
por: Pan, Xiao-dong, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_am6q0icrbuaoqt9kt27521qnn0